Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0S0XD
|
|||
| Former ID |
DIB019456
|
|||
| Drug Name |
PMID22902653C35
|
|||
| Synonyms |
GTPL8119; BDBM50390795
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2] | |
| Structure |
 |
Download2D MOL
|
||
| Formula |
C20H14Cl2N6O2S
|
|||
| Canonical SMILES |
CC(=O)NC1=NC=C(S1)C2=CC(=NC(=N2)C3=NC=CN=C3)C4=C(C=C(C=C4Cl)OC)Cl
|
|||
| InChI |
1S/C20H14Cl2N6O2S/c1-10(29)26-20-25-9-17(31-20)14-7-15(18-12(21)5-11(30-2)6-13(18)22)28-19(27-14)16-8-23-3-4-24-16/h3-9H,1-2H3,(H,25,26,29)
|
|||
| InChIKey |
XACSASLXEAYEEO-UHFFFAOYSA-N
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | LIM domain kinase-1 (LIMK-1) | Target Info | Inhibitor | [2] |
| LIM domain kinase-2 (LIMK-2) | Target Info | Inhibitor | [2] | |
| Testis-specific kinase 1 (TESK1) | Target Info | Inhibitor | [2] | |
| Testis-specific kinase 2 (TESK2) | Target Info | Inhibitor | [2] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells. J Biol Chem. 2001 Aug 17;276(33):31449-58. | |||
| REF 2 | Modulation of cofilin phosphorylation by inhibition of the Lim family kinases. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5995-8. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.