Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0S0NB
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| Former ID |
DIB021110
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| Drug Name |
UCCF-853
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| Synonyms |
UCCF-853; 625458-06-2; 1-(3-chlorophenyl)-5-trifluoromethyl-3-hydrobenzimidazol-2-one; GTPL4338; SCHEMBL15070016; DTXSID40590778; ZINC22115075; 1-(3-Chloro-phenyl)-5-trifluoromethyl-1,3-dihydro-benzoimidazol-2-one; KB-08685; KB-08684; EC-000.1912; 1-(3-chlorophenyl)-5-trifluoromethyl-1,3-dihydrobenzoimidazol-2-one; 1-(3-Chlorophenyl)-5-(trifluoromethyl)-1,3-dihydro-2H-benzimidazol-2-one
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C14H8ClF3N2O
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| Canonical SMILES |
C1=CC(=CC(=C1)Cl)N2C3=C(C=C(C=C3)C(F)(F)F)NC2=O
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| InChI |
1S/C14H8ClF3N2O/c15-9-2-1-3-10(7-9)20-12-5-4-8(14(16,17)18)6-11(12)19-13(20)21/h1-7H,(H,19,21)
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| InChIKey |
NMPJFFWYEIIGFW-UHFFFAOYSA-N
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| CAS Number |
CAS 625458-06-2
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | cAMP-dependent chloride channel (CFTR) | Target Info | Activator | [2] |
| KEGG Pathway | ABC transporters | |||
| cAMP signaling pathway | ||||
| AMPK signaling pathway | ||||
| Gastric acid secretion | ||||
| Pancreatic secretion | ||||
| Bile secretion | ||||
| Vibrio cholerae infection | ||||
| Reactome | ABC-family proteins mediated transport | |||
| WikiPathways | ABC-family proteins mediated transport | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4338). | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 707). | |||
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