Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0RF7O
|
|||
| Former ID |
DIB020376
|
|||
| Drug Name |
ML347
|
|||
| Synonyms |
ML-347
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
|
||
| Formula |
C22H16N4O
|
|||
| Canonical SMILES |
COC1=CC=C(C=C1)C2=CN3C(=C(C=N3)C4=C5C=CC=NC5=CC=C4)N=C2
|
|||
| InChI |
1S/C22H16N4O/c1-27-17-9-7-15(8-10-17)16-12-24-22-20(13-25-26(22)14-16)18-4-2-6-21-19(18)5-3-11-23-21/h2-14H,1H3
|
|||
| InChIKey |
FVRYPYDPKSZGNS-UHFFFAOYSA-N
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Activin receptor-like kinase 2 (ALK-2) | Target Info | Inhibitor | [1] |
| Activin receptor-like kinase-1 (ACVRL1) | Target Info | Inhibitor | [1] | |
| Bone morphogenetic protein receptor (BMPR2) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| TGF-beta signaling pathway | ||||
| Hippo signaling pathway | ||||
| Signaling pathways regulating pluripotency of stem cells | ||||
| Panther Pathway | TGF-beta signaling pathway | |||
| Pathway Interaction Database | ALK1 pathway | |||
| ALK1 signaling events | ||||
| WikiPathways | Endochondral Ossification | |||
| Ectoderm Differentiation | ||||
| Mesodermal Commitment Pathway | ||||
| Endoderm Differentiation | ||||
| Hair Follicle Development: Cytodifferentiation (Part 3 of 3) | ||||
| Hair Follicle Development: Induction (Part 1 of 3) | ||||
| Signaling by BMP | ||||
| Integrated Breast Cancer Pathway | ||||
| Heart Development | ||||
| BMP Signalling and Regulation | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.