Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0R6JG
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| Former ID |
DIB018982
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| Drug Name |
BIX 02188
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| Synonyms |
BIX02188; BIX-02188
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C25H24N4O2
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| Canonical SMILES |
CN(C)CC1=CC(=CC=C1)N=C(C2=CC=CC=C2)C3=C(NC4=C3C=CC(=C4)C(=O)N)O
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| InChI |
1S/C25H24N4O2/c1-29(2)15-16-7-6-10-19(13-16)27-23(17-8-4-3-5-9-17)22-20-12-11-18(24(26)30)14-21(20)28-25(22)31/h3-14,28,31H,15H2,1-2H3,(H2,26,30)
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| InChIKey |
WGPXKFOFEXJMBD-UHFFFAOYSA-N
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| CAS Number |
CAS 1094614-84-2
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | ERK activator kinase 5 (MAP2K5) | Target Info | Inhibitor | [1] |
| Panther Pathway | CCKR signaling map ST | |||
| Pathway Interaction Database | ErbB1 downstream signaling | |||
| Trk receptor signaling mediated by the MAPK pathway | ||||
| WikiPathways | Insulin Signaling | |||
| EGF/EGFR Signaling Pathway | ||||
| MAPK Signaling Pathway | ||||
| Focal Adhesion | ||||
| Cardiac Hypertrophic Response | ||||
| BDNF signaling pathway | ||||
| Signaling Pathways in Glioblastoma | ||||
| NGF signalling via TRKA from the plasma membrane | ||||
| Integrin-mediated Cell Adhesion | ||||
| MicroRNAs in cardiomyocyte hypertrophy | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Identification of pharmacological inhibitors of the MEK5/ERK5 pathway. Biochem Biophys Res Commun. 2008 Dec 5;377(1):120-5. | |||
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