Drug Information
Drug General Information | Top | |||
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Drug ID |
D0R6BR
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Former ID |
DAP000686
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Drug Name |
Amobarbital
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Synonyms |
AMAL; Amasust; Amital; Amobarbitale; Amobarbitalum; Amobarbitone; Amospan; Amybal; Amylbarbitone; Amylobarbital; Amylobarbitone; Amytal; Barbamil; Barbamyl; Binoctal; Dorlotyn; Dormytal; Eunoctal; Isomyl; Isomytal; Mylodorm; Pentymal; Pentymalum; Robarb; Schiwanox; Sednotic; Somnal; Stadadorm; Sumital; Talamo; Amobarbital suppository dosage form; Amobarbitale [DCIT]; Barbamyl acid; Component of Dexamyl; Ethylisopentylbarbituric acid; Isoamylethylbarbituric acid; Amobarbital [INN:JAN]; Amobarbitalum [INN-Latin]; Component of 15-90; Component of Amo-Dextrosule; Component of Q-Caps; Isomytal (TN); Amobarbital (JP15/INN); 5-Ethyl-5-(3-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione; 5-Ethyl-5-(3-methylbutyl)barbituric acid;5-Ethyl-5-isoamylbarbituric acid; 5-Ethyl-5-isoamylmalonyl urea; 5-Ethyl-5-isopentylbarbituric acid; 5-Ethyl-5-isopentylbarbitursaeure; 5-Isoamyl-5-ethylbarbituric acid; 5-ethyl-5-(3-methylbutyl)-1,3-diazinane-2,4,6-trione; 5-ethyl-5-(3-methylbutyl)pyrimidine-2,4,6(1H,3H,5H)-trione
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Drug Type |
Small molecular drug
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Indication | Insomnia [ICD-11: 7A00-7A0Z] | Approved | [1], [2] | |
Therapeutic Class |
Hypnotics and Sedatives
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Structure |
Download2D MOL |
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Formula |
C11H18N2O3
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Canonical SMILES |
CCC1(C(=O)NC(=O)NC1=O)CCC(C)C
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InChI |
1S/C11H18N2O3/c1-4-11(6-5-7(2)3)8(14)12-10(16)13-9(11)15/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16)
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InChIKey |
VIROVYVQCGLCII-UHFFFAOYSA-N
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CAS Number |
CAS 57-43-2
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PubChem Compound ID | ||||
PubChem Substance ID |
9739, 75927, 90916, 415152, 4436381, 7847621, 7978707, 8151471, 10527891, 11135452, 11336169, 11361408, 11462380, 11533324, 12587661, 12587662, 15415185, 29221343, 46508165, 47291211, 47891734, 48413208, 48414905, 49857182, 50381613, 53789674, 57321181, 87691678, 93167109, 103165869, 104299793, 124954079, 125308270, 126677737, 129480778, 134337975, 134970867, 137003749, 137240387, 138744645, 144206419, 160964641, 164835791, 175267584, 176262155, 179094982, 179225502, 198993173, 223366878, 223674396
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ChEBI ID |
CHEBI:2673
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ADReCS Drug ID | BADD_D00126 | |||
SuperDrug ATC ID |
N05CA02
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SuperDrug CAS ID |
cas=000057432
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Target and Pathway | Top | |||
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Target(s) | GABA(A) receptor alpha-1 (GABRA1) | Target Info | Antagonist | [3], [4] |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Retrograde endocannabinoid signaling | ||||
GABAergic synapse | ||||
Morphine addiction | ||||
Nicotine addiction | ||||
Reactome | Ligand-gated ion channel transport | |||
GABA A receptor activation | ||||
WikiPathways | SIDS Susceptibility Pathways | |||
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
Iron uptake and transport |
References | Top | |||
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REF 1 | Drug information of Amobarbital, 2008. eduDrugs. | |||
REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
REF 3 | DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. | |||
REF 4 | Effect of barbiturates on polyphosphoinositide biosynthesis and protein kinase C activity in synaptosomes. Neuropharmacology. 1989 Dec;28(12):1317-23. |
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