Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0R0RW
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| Former ID |
DIB011878
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| Drug Name |
1D05
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| Synonyms |
Humanized monoclonal antibody (coronary heart disease), Merck
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| Drug Type |
Antibody
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| Indication | Coronary artery disease [ICD-11: BA80; ICD-10: I25.1, I25.4] | Investigative | [1] | |
| Company |
Merck & Co Inc
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Proprotein convertase subtilisin/kexin type 9 (PCSK9) | Target Info | . | [1] |
| WikiPathways | PCSK9-mediated LDLR degradation | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo. J Lipid Res. 2011 Jan;52(1):78-86. | |||
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