Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0QL3P
|
|||
| Former ID |
DAP000528
|
|||
| Drug Name |
Oxcarbazepine
|
|||
| Synonyms |
Epilexter; Epliga; Oxacarbazepine; Oxcarbamazepine; Oxcarbazepime; Oxcarbazepina; Oxcarbazepinum; Timox; Trileptal; Desitin brand of oxcarbazepine; Novartis brand of oxcarbazepine; Oxcarbazepine [INN]; GP 47680; O0363; GP-47680; KIN-493; Oxaleptal (TN); Oxcarbazepina [INN-Spanish]; Oxcarbazepinum [INN-Latin]; SPN-804; Trileptal (TN); Oxcarbazepine (USAN/INN); 10,11-Dihydro-10-oxo-5H-debenz(b,f)azepine-5-carboxamide; 10,11-Dihydro-10-oxo-5H-dibenz(b,f)azepine-5-carboxamide; 10,11-Dihydro-10-oxo-5H-dibenz[b,f]azepine-5-carboxamide; 10,11-Dihydro-10-oxo-5H-dibenzo[b,f]azepine-5-carboxamide; 10,11-Dihydro-10-oxo-5h-dibenz[b,f]azepine-5-carboxamide; 10-Oxo-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide; 5-oxo-6H-benzo[b][1]benzazepine-11-carboxamide
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Epilepsy [ICD-11: 8A60-8A68] | Approved | [1], [2] | |
| Therapeutic Class |
Anticonvulsants
|
|||
| Company |
Norvatis Phamaceuticals Corporation
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C15H12N2O2
|
|||
| Canonical SMILES |
C1C2=CC=CC=C2N(C3=CC=CC=C3C1=O)C(=O)N
|
|||
| InChI |
1S/C15H12N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8H,9H2,(H2,16,19)
|
|||
| InChIKey |
CTRLABGOLIVAIY-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 28721-07-5
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID |
9695, 866068, 866523, 7784956, 7847599, 7980216, 8173559, 11364569, 11367131, 11369693, 11372776, 11374387, 11377855, 11484081, 11488299, 11491484, 11492449, 11495489, 11528646, 12013820, 15196775, 24724563, 26612687, 26679796, 26719673, 26747194, 26747195, 34676003, 46386767, 46507580, 47291388, 47365462, 50085868, 50105170, 53790510, 57311661, 75522661, 81040908, 81093135, 87561105, 92124721, 92307920, 92308514, 92309109, 92711414, 93166236, 96099912, 99233256, 99437127, 103292787
|
|||
| ChEBI ID |
CHEBI:7824
|
|||
| ADReCS Drug ID | BADD_D01637 | |||
| SuperDrug ATC ID |
N03AF02
|
|||
| SuperDrug CAS ID |
cas=028721075
|
|||
| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
|
Studied Microbe: Bacteroides dorei DSM 17855
Show/Hide Hierarchy
|
[3] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Oxcarbazepine can be metabolized by Bacteroides dorei DSM 17855 (log2FC = -0.441; p = 0.048). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Voltage-gated sodium channel alpha Nav1.9 (SCN11A) | Target Info | Blocker | [4], [5] |
| Reactome | Interaction between L1 and Ankyrins | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7254). | |||
| REF 2 | Use of second-generation antiepileptic drugs in the pediatric population. Paediatr Drugs. 2008;10(4):217-54. | |||
| REF 3 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
| REF 4 | Debate: Does genetic information in humans help us treat patients PRO--genetic information in humans helps us treat patients. CON--genetic information does not help at all. Epilepsia. 2008 Dec;49 Suppl 9:13-24. | |||
| REF 5 | Antiepileptic drugs in non-epilepsy disorders: relations between mechanisms of action and clinical efficacy. CNS Drugs. 2008;22(1):27-47. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.