Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0Q9YT
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| Former ID |
DAP000538
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| Drug Name |
Tetrahydrobiopterin
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| Synonyms |
tetrahydrobiopterin; 17528-72-2; 5,6,7,8-tetrahydrobiopterin; BRN 0544742; CHEBI:15372; 5,6,7,8-Tetrahydro-2-amino-6-(1,2-dihydroxypropyl)-4(1H)-pteridinone; L-erythro-2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4(3H)-pteridinon; (1R,2S)-(2-Amino-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)-1,2-propandiol; 5,6,7,8-erythro-tetrahydrobiopterin; 2-amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydropteridin-4(3H)-one; Dapropterin; Phenoptin
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| Drug Type |
Small molecular drug
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| Indication | Malnutrition [ICD-11: 5B50-5B71] | Approved | [1], [2] | |
| Therapeutic Class |
Dietary supplement
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| Structure |
 |
Download2D MOL |
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| Formula |
C9H15N5O3
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| Canonical SMILES |
CC(C(C1CNC2=C(N1)C(=O)NC(=N2)N)O)O
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| InChI |
1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17)
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| InChIKey |
FNKQXYHWGSIFBK-UHFFFAOYSA-N
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| CAS Number |
CAS 17528-72-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
3570, 7886190, 7888050, 7890758, 11567654, 14847463, 15196443, 16725801, 26738584, 34709536, 47277070, 48395336, 56312756, 57312919, 58712668, 79902433, 92298110, 93581510, 96025190, 104223501, 104234358, 104344349, 134361847, 135004616, 137210663, 137242080, 137680009, 144080912, 160852798, 162173351, 162224078, 164765359, 175267933, 178101959, 179150945, 184536615, 223573380, 223573381, 224666945, 226607067, 241112763, 242081928, 250136857, 252337579
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| ChEBI ID |
CHEBI:15372
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| ADReCS Drug ID | BADD_D01987 ; BADD_D01988 ; BADD_D02185 | |||
| SuperDrug ATC ID |
A16AX07
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Tyrosine 3-monooxygenase (TH) | Target Info | Cofactor | [3] |
| BioCyc | Catecholamine biosynthesis | |||
| KEGG Pathway | Tyrosine metabolism | |||
| Metabolic pathways | ||||
| Dopaminergic synapse | ||||
| Prolactin signaling pathway | ||||
| Parkinson's disease | ||||
| Cocaine addiction | ||||
| Amphetamine addiction | ||||
| Alcoholism | ||||
| Panther Pathway | Adrenaline and noradrenaline biosynthesis | |||
| Parkinson disease | ||||
| Dopamine receptor mediated signaling pathway | ||||
| Nicotine pharmacodynamics pathway | ||||
| Pathwhiz Pathway | Catecholamine Biosynthesis | |||
| Pathway Interaction Database | ATF-2 transcription factor network | |||
| AP-1 transcription factor network | ||||
| p38 signaling mediated by MAPKAP kinases | ||||
| Alpha-synuclein signaling | ||||
| WikiPathways | Monoamine Transport | |||
| SIDS Susceptibility Pathways | ||||
| Biogenic Amine Synthesis | ||||
| Dopaminergic Neurogenesis | ||||
| Metabolism of amino acids and derivatives | ||||
| Dopamine metabolism | ||||
| Parkinsons Disease Pathway | ||||
| Nicotine Activity on Dopaminergic Neurons | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5276). | |||
| REF 2 | Sapropterin: a new therapeutic agent for phenylketonuria. Ann Pharmacother. 2009 Sep;43(9):1466-73. | |||
| REF 3 | Biochemistry of postmortem brains in Parkinson's disease: historical overview and future prospects. J Neural Transm Suppl. 2007;(72):113-20. | |||
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