Drug Information
Drug General Information | Top | |||
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Drug ID |
D0Q7BG
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Former ID |
DIB018835
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Drug Name |
AMG-837
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Synonyms |
AMG 837; AMG837
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL
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Formula |
C26H21F3O3
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Canonical SMILES |
CC#CC(CC(=O)O)C1=CC=C(C=C1)OCC2=CC(=CC=C2)C3=CC=C(C=C3)C(F)(F)F
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InChI |
1S/C26H21F3O3/c1-2-4-21(16-25(30)31)20-9-13-24(14-10-20)32-17-18-5-3-6-22(15-18)19-7-11-23(12-8-19)26(27,28)29/h3,5-15,21H,16-17H2,1H3,(H,30,31)/t21-/m0/s1
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InChIKey |
ZOPNBMMVVZRSGH-NRFANRHFSA-N
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CAS Number |
CAS 865231-46-5
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Free fatty acid receptor 1 (GPR40) | Target Info | Agonist | [2] |
KEGG Pathway | Insulin secretion | |||
Reactome | G alpha (q) signalling events | |||
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | ||||
WikiPathways | GPCRs, Class A Rhodopsin-like | |||
Incretin Synthesis, Secretion, and Inactivation | ||||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
Integration of energy metabolism | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6485). | |||
REF 2 | Identification and pharmacological characterization of multiple allosteric binding sites on the free fatty acid 1 receptor. Mol Pharmacol. 2012 Nov;82(5):843-59. |
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