Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0Q5BU
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| Former ID |
DIB000926
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| Drug Name |
MSH-1001
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| Synonyms |
DNB-001; KR-31378; KR-31378); K+ channel activating compounds, Dongbu/KRICT
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| Indication | Ocular hypertension [ICD-11: 9C61.01; ICD-9: 365.04] | Phase 2 | [1] | |
| Company |
Danube Pharmaceuticals Inc; Korea Research Institute of Chemical Technology
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| Structure |
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Download2D MOL |
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| Formula |
C22H27N5O4
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| Canonical SMILES |
CC1(C(C(C2=C(O1)C=CC(=C2)N)NC(=NCC3=CC=CC=C3)NC#N)O)C(OC)OC
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| InChI |
1S/C22H27N5O4/c1-22(20(29-2)30-3)19(28)18(16-11-15(24)9-10-17(16)31-22)27-21(26-13-23)25-12-14-7-5-4-6-8-14/h4-11,18-20,28H,12,24H2,1-3H3,(H2,25,26,27)/t18-,19+,22+/m1/s1
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| InChIKey |
OZHUPJHJQIEDFA-DXIQSLLYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Potassium channel unspecific (KC) | Target Info | Opener | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023795) | |||
| REF 2 | KR-31378, a potassium-channel opener, induces the protection of retinal ganglion cells in rat retinal ischemic models. J Pharmacol Sci. 2009 Apr;109(4):511-7. | |||
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