Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0Q4YI
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| Former ID |
DIB015290
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| Drug Name |
Trimetazidine
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| Synonyms |
Trimetazidine dihydrochloride; 13171-25-0; 1-(2,3,4-Trimethoxybenzyl)piperazine dihydrochloride; Kyurinett; Trimetazidine hydrochloride; Trimetajust; Lubomail; Yosimilon; Vastarel; Trimetazidine HCl; Trimetazidine (dihydrochloride); 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine dihydrochloride; Trimetazidine DiHCl; UNII-48V6723Z1P; EINECS 236-117-0; S 4004; 48V6723Z1P; Piperazine, 1-[(2,3,4-trimethoxyphenyl)methyl]-, dihydrochloride; DSSTox_RID_80858; DSSTox_CID_25407; DSSTox_GSID_45407; W-108326; Piperazine, 1-(2,3,4-trimethoxyb
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| Drug Type |
Small molecular drug
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| Indication | Angina pectoris [ICD-11: BA40; ICD-9: 413] | Approved | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C14H22N2O3
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| Canonical SMILES |
COC1=C(C(=C(C=C1)CN2CCNCC2)OC)OC
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| InChI |
1S/C14H22N2O3/c1-17-12-5-4-11(13(18-2)14(12)19-3)10-16-8-6-15-7-9-16/h4-5,15H,6-10H2,1-3H3
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| InChIKey |
UHWVSEOVJBQKBE-UHFFFAOYSA-N
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| CAS Number |
CAS 5011-34-7
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:94789
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides fragilis str. 3397 T10
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Trimetazidine dihydrochloride can be metabolized by Bacteroides fragilis str. 3397 T10 (log2FC = -0.72; p = 0.013). | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
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