Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0Q4LG
|
|||
| Former ID |
DIB011485
|
|||
| Drug Name |
IT-139
|
|||
| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 1 | [1] | |
| Company |
Intezyne
|
|||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Endoplasmic reticulum chaperone BiP (HSPA5) | Target Info | Inhibitor | [2] |
| KEGG Pathway | Protein export | |||
| Protein processing in endoplasmic reticulum | ||||
| Antigen processing and presentation | ||||
| Thyroid hormone synthesis | ||||
| Prion diseases | ||||
| NetPath Pathway | TSH Signaling Pathway | |||
| TCR Signaling Pathway | ||||
| Panther Pathway | Apoptosis signaling pathway | |||
| Parkinson disease | ||||
| Pathwhiz Pathway | Retinol Metabolism | |||
| Reactome | Platelet degranulation | |||
| Regulation of HSF1-mediated heat shock response | ||||
| WikiPathways | MAPK Signaling Pathway | |||
| Apoptosis-related network due to altered Notch3 in ovarian cancer | ||||
| Activation of Chaperone Genes by ATF6-alpha | ||||
| Parkin-Ubiquitin Proteasomal System pathway | ||||
| Unfolded Protein Response | ||||
| Response to elevated platelet cytosolic Ca2+ | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800034247) | |||
| REF 2 | NKP-1339, a first-in-class anticancer drug showing mild side effects and activity in patients suffering from advanced refractory cancer. BMC Pharmacol Toxicol. 2012; 13(Suppl 1): A82. | |||
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