Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0Q2PF
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| Former ID |
DIB014201
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| Drug Name |
LY-293284
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| Synonyms |
LY-293284; LY 293284; 141318-62-9; LY293284; 6-Acetyl-4-(di-n-propylamino)-1,3,4,5-tetrahydrobenz(c,d)indole; LY-293,284; 1-(4-Dipropylamino-1,3,4,5-tetrahydro-benzo[cd]indol-6-yl)-ethanone; Ethanone, 1-(4-(dipropylamino)-1,3,4,5-tetrahydrobenz(cd)indol-6-yl)-, (R)-; GTPL19; AC1L30TM; SCHEMBL6902000; DTXSID70161692; LS-173111
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| Drug Type |
Small molecular drug
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| Indication | Anxiety disorder [ICD-11: 6B00-6B0Z; ICD-10: R45.0] | Terminated | [1], [2] | |
| Company |
Eli Lilly & Co
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| Structure |
 |
Download2D MOL |
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| Formula |
C19H26N2O
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| Canonical SMILES |
CCCN(CCC)C1CC2=CNC3=C2C(=C(C=C3)C(=O)C)C1
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| InChI |
1S/C19H26N2O/c1-4-8-21(9-5-2)15-10-14-12-20-18-7-6-16(13(3)22)17(11-15)19(14)18/h6-7,12,15,20H,4-5,8-11H2,1-3H3/t15-/m0/s1
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| InChIKey |
CKYZLYQSDNLGPT-HNNXBMFYSA-N
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| CAS Number |
CAS 141318-62-9
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 1A receptor (HTR1A) | Target Info | Agonist | [3] |
| KEGG Pathway | cAMP signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Serotonergic synapse | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| 5HT1 type receptor mediated signaling pathway | ||||
| Reactome | Serotonin receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | Serotonin HTR1 Group and FOS Pathway | |||
| SIDS Susceptibility Pathways | ||||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 19). | |||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003567) | |||
| REF 3 | Pharmacological characterization of LY293284: A 5-HT1A receptor agonist with high potency and selectivity. J Pharmacol Exp Ther. 1994 Sep;270(3):1270-81. | |||
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