Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0Q2LG
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| Former ID |
DIB018671
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| Drug Name |
5S-HPETE
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| Synonyms |
5-(S)-hydroperoxyeicosatetraenoic acid; 5S-HpETE
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C20H32O4
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| Canonical SMILES |
CCCCCC=CCC=CCC=CC=CC(CCCC(=O)O)OO
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| InChI |
1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
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| InChIKey |
JNUUNUQHXIOFDA-JGKLHWIESA-N
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| CAS Number |
CAS 71774-08-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
7733, 4266118, 8143290, 8616390, 15988963, 26754757, 26754758, 39289806, 47515057, 48258936, 49964840, 50110770, 53801093, 57357866, 80066874, 92309861, 99300775, 99302293, 104046397, 113853964, 126523872, 131279964, 135151068, 142970203, 162226029, 179205513, 227610724, 250132992, 252455585, 252465547
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| ChEBI ID |
CHEBI:15632
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Oxoeicosanoid receptor 1 (OXER1) | Target Info | Agonist | [2] |
| Transient receptor potential cation channel V1 (TRPV1) | Target Info | Activator | [3] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Inflammatory mediator regulation of TRP channels | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Pathway Interaction Database | Trk receptor signaling mediated by the MAPK pathway | |||
| Trk receptor signaling mediated by PI3K and PLC-gamma | ||||
| Reactome | TRP channels | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2483). | |||
| REF 2 | TG1019/OXE, a Galpha(i/o)-protein-coupled receptor, mediates 5-oxo-eicosatetraenoic acid-induced chemotaxis. Biochem Biophys Res Commun. 2005 Sep 9;334(4):987-95. | |||
| REF 3 | Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances. Proc Natl Acad Sci U S A. 2000 May 23;97(11):6155-60. | |||
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