Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0PW7C
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| Former ID |
DAP000442
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| Drug Name |
Cefaclor
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| Synonyms |
Alenfral; Alfacet; Alfatil; CCL; Ceclor; Cefaclorum; Distaclor; Kefolor; Panacef; Panoral; Alfatil Kapseln; Cefaclor anhydrous; Cefaclor hydrate; Cefaclor monohydrate; Dystaclor MR; Kefolor Suspension; Muco Panoral; Lilly 99638 hydrate; Alenfral (TN); Ceclor (TN); Cefaclor (JP15); Cefaclor (USP); Distaclor (TN); Keflor (TN); L-Kefral; Raniclor (TN); S-6472; Cefaclor-1-wasser; Cefaclor [USAN:INN:BAN:JAN]; Ceclor, Distaclor, Keflor, Raniclor, Cefaclor; (6R,7R)-7-((R)-2-Amino-2-phenylacetamido)-3-chloro-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid monohydrate; (6R,7R)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid hydrate; (6R,7R)-7-{[(2R)-2-amino-2-phenylacetyl]amino}-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 3-Chloro-7-D-(2-phenylglycinamido)-3-cephem-4-carboxylic acid; 3-Chloro-7-D-(2-phenylglycinamido)-3-cephem-4-carboxylic acid monohydrate; 7-(2-Amino-2-phenyl-acetylamino)-3-chloro-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 7beta-{[(2R)-2-amino-2-phenylacetyl]amino}-3-chloro-3,4-didehydrocepham-4-carboxylic acid
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| Drug Type |
Small molecular drug
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| Indication | Bacterial infection [ICD-11: 1A00-1C4Z; ICD-10: A00-B99] | Approved | [1] | |
| Therapeutic Class |
Antibiotics
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| Company |
Eli Lilly
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| Structure |
 |
Download2D MOL |
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| Formula |
C15H14ClN3O4S
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| Canonical SMILES |
C1C(=C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=CC=C3)N)C(=O)O)Cl
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| InChI |
1S/C15H14ClN3O4S/c16-8-6-24-14-10(13(21)19(14)11(8)15(22)23)18-12(20)9(17)7-4-2-1-3-5-7/h1-5,9-10,14H,6,17H2,(H,18,20)(H,22,23)/t9-,10-,14-/m1/s1
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| InChIKey |
QYIYFLOTGYLRGG-GPCCPHFNSA-N
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| CAS Number |
CAS 53994-73-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9094, 625389, 855765, 7847322, 7978871, 8181891, 11342218, 11362401, 11363964, 11366526, 11369088, 11372875, 11373525, 11377250, 11466513, 11467130, 11467633, 11468250, 11484973, 11486006, 11486818, 11487803, 11489005, 11491673, 11491908, 11494884, 12013565, 14803830, 14852885, 24278331, 26612067, 26680440, 29215008, 34715524, 46386958, 46507693, 47425324, 47425325, 47574401, 47647541, 47796074, 48020027, 48095565, 48170475, 48244405, 48244406, 48415708, 48484011, 49681804, 49698517
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| ChEBI ID |
CHEBI:3478
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| ADReCS Drug ID | BADD_D00378 | |||
| SuperDrug ATC ID |
J01DC04
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| SuperDrug CAS ID |
cas=053994733
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacillales | ||||
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Studied Microbe: Staphylococcus
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Staphylococcus was increased by Cefaclor. | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides
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[3] | |||
| Hierarchy | ||||
| Abundance Change | No significant change | |||
| Experimental Species | Human | Experimental Sample | Faeces, saliva | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Bacteroides was not significantly changed by Cefaclor. | |||
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Studied Microbe: Bacteroides vulgatus
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides vulgatus was decreased by Cefaclor hydrate (adjusted p-values: 9.05E-06). | |||
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Studied Microbe: Odoribacter splanchnicus
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Odoribacter splanchnicus was decreased by Cefaclor hydrate (adjusted p-values: 5.04E-06). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
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Studied Microbe: Bifidobacterium adolescentis
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bifidobacterium adolescentis was decreased by Cefaclor hydrate (adjusted p-values: 5.04E-06). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Campylobacterales | ||||
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Studied Microbe: Helicobacteraceae
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|
[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Non pregnant | |||
| Description | The abundance of Helicobacteraceae was decreased by Cefaclor (p = 0.01). | |||
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Studied Microbe: Helicobacteraceae
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Pregnant | |||
| Description | The abundance of Helicobacteraceae was decreased by Cefaclor (p = 0.01). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Coriobacteriales | ||||
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Studied Microbe: Collinsella aerofaciens
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Collinsella aerofaciens was decreased by Cefaclor hydrate (adjusted p-values: 4.80E-07). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eggerthellales | ||||
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Studied Microbe: Eggerthella lenta
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eggerthella lenta was decreased by Cefaclor hydrate (adjusted p-values: 4.19E-05). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Enterobacterales | ||||
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Studied Microbe: Enterobacter
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Pregnant | |||
| Description | The abundance of Enterobacter was increased by Cefaclor (p = 0.01). | |||
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Studied Microbe: Enterobacteriaceae
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[3] | |||
| Hierarchy | ||||
| Abundance Change | No significant change | |||
| Experimental Species | Human | Experimental Sample | Faeces, saliva | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Enterobacteriaceae was not significantly changed by Cefaclor. | |||
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Studied Microbe: Enterobacteriaceae
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Non pregnant | |||
| Description | The abundance of Enterobacteriaceae was increased by Cefaclor (p = 0.002). | |||
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Studied Microbe: Enterobacteriaceae
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Pregnant | |||
| Description | The abundance of Enterobacteriaceae was increased by Cefaclor (p = 0.002). | |||
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Studied Microbe: Shigella
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Pregnant | |||
| Description | The abundance of Shigella was increased by Cefaclor (p = 0.01). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Blautia obeum
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Blautia obeum was decreased by Cefaclor hydrate (adjusted p-values: 1.20E-06). | |||
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Studied Microbe: Clostridium
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[3] | |||
| Hierarchy | ||||
| Abundance Change | No significant change | |||
| Experimental Species | Human | Experimental Sample | Faeces, saliva | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Clostridium was not significantly changed by Cefaclor. | |||
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Studied Microbe: Clostridium difficile
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Clostridium difficile was increased by Cefaclor. | |||
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Studied Microbe: Clostridium perfringens
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Clostridium perfringens was decreased by Cefaclor hydrate (adjusted p-values: 2.40E-06). | |||
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Studied Microbe: Coprococcus comes
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Coprococcus comes was decreased by Cefaclor hydrate (adjusted p-values: 4.83E-03). | |||
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Studied Microbe: Dorea formicigenerans
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Dorea formicigenerans was decreased by Cefaclor hydrate (adjusted p-values: 1.21E-04). | |||
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Studied Microbe: Eubacterium
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[3] | |||
| Hierarchy | ||||
| Abundance Change | No significant change | |||
| Experimental Species | Human | Experimental Sample | Faeces, saliva | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Eubacterium was not significantly changed by Cefaclor. | |||
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Studied Microbe: Eubacterium rectale
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eubacterium rectale was decreased by Cefaclor hydrate (adjusted p-values: 7.95E-04). | |||
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Studied Microbe: Roseburia hominis
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Roseburia hominis was decreased by Cefaclor hydrate (adjusted p-values: 1.59E-05). | |||
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Studied Microbe: Roseburia intestinalis
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Roseburia intestinalis was decreased by Cefaclor hydrate (adjusted p-values: 7.52E-04). | |||
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Studied Microbe: Ruminococcus bromii
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus bromii was decreased by Cefaclor hydrate (adjusted p-values: 6.13E-06). | |||
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Studied Microbe: Ruminococcus gnavus
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus gnavus was decreased by Cefaclor hydrate (adjusted p-values: 9.43E-03). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Hyphomicrobiales | ||||
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Studied Microbe: Methylobacteriaceae
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Non pregnant | |||
| Description | The abundance of Methylobacteriaceae was increased by Cefaclor (p = 0.009). | |||
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Studied Microbe: Methylobacteriaceae
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Pregnant | |||
| Description | The abundance of Methylobacteriaceae was increased by Cefaclor (p = 0.009). | |||
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Studied Microbe: Methylobacterium
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Pregnant | |||
| Description | The abundance of Methylobacterium was increased by Cefaclor (p = 0.01). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Lactobacillales | ||||
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Studied Microbe: Enterococcus
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[3] | |||
| Hierarchy | ||||
| Abundance Change | No significant change | |||
| Experimental Species | Human | Experimental Sample | Faeces, saliva | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Enterococcus was not significantly changed by Cefaclor. | |||
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Studied Microbe: Lactobacillaceae
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Non pregnant | |||
| Description | The abundance of Lactobacillaceae was decreased by Cefaclor (p = 0.008). | |||
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Studied Microbe: Lactobacillus
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[3] | |||
| Hierarchy | ||||
| Abundance Change | No significant change | |||
| Experimental Species | Human | Experimental Sample | Faeces, saliva | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Lactobacillus was not significantly changed by Cefaclor. | |||
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Studied Microbe: Lactococcus
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Pregnant | |||
| Description | The abundance of Lactococcus was increased by Cefaclor (p = 0.01). | |||
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Studied Microbe: Streptococcus
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[3] | |||
| Hierarchy | ||||
| Abundance Change | No significant change | |||
| Experimental Species | Human | Experimental Sample | Faeces, saliva | |
| Disease or Condition | Healthy | |||
| Description | The abundance of Streptococcus was not significantly changed by Cefaclor. | |||
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Studied Microbe: Streptococcus parasanguinis
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Streptococcus parasanguinis was decreased by Cefaclor hydrate (adjusted p-values: 7.52E-07). | |||
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Studied Microbe: Streptococcus salivarius
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Streptococcus salivarius was decreased by Cefaclor hydrate (adjusted p-values: 5.51E-07). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Moraxellales | ||||
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Studied Microbe: Moraxellaceae
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Non pregnant | |||
| Description | The abundance of Moraxellaceae was increased by Cefaclor (p = 0.003). | |||
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Studied Microbe: Moraxellaceae
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Pregnant | |||
| Description | The abundance of Moraxellaceae was increased by Cefaclor (p = 0.003). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Mycoplasmatales | ||||
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Studied Microbe: Mycoplasmataceae
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[5] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Sprague-Dawley rat | Experimental Sample | Faeces | |
| Disease or Condition | Non pregnant | |||
| Description | The abundance of Mycoplasmataceae was decreased by Cefaclor (p = 0.045). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Veillonellales | ||||
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Studied Microbe: Veillonella parvula
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[4] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Veillonella parvula was decreased by Cefaclor hydrate (adjusted p-values: 5.85E-06). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Bacterial Penicillin binding protein (Bact PBP) | Target Info | Binder | [6] |
| References | Top | |||
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| REF 1 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 062206. | |||
| REF 2 | Bowel flora changes in humans receiving cefixime (CL 284,635) or cefaclor. Antimicrob Agents Chemother. 1987 Mar;31(3):443-6. | |||
| REF 3 | Impact of cefaclor on the normal human oropharyngeal and intestinal microflora. Scand J Infect Dis. 1987;19(6):681-5. | |||
| REF 4 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
| REF 5 | Metagenomic Analysis of Antibiotic-Induced Changes in Gut Microbiota in a Pregnant Rat Model. Front Pharmacol. 2016 Apr 28;7:104. | |||
| REF 6 | Antibacterial activity of oral cephems against various clinically isolated strains and evaluation of efficacy based on the pharmacokinetics/pharmacodynamics theory. Jpn J Antibiot. 2004 Dec;57(6):465-74. | |||
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