Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0PV4H
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| Former ID |
DIB009403
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| Drug Name |
Legumain-cleavable doxorubicin prodrugs
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| Synonyms |
Legubicin; LEG-2; LEG-3; Legumain-cleavable doxorubicin prodrugs (cancer); Legumain-cleavabledoxorubicin prodrugs (cancer), Affinity Pharmaceuticals
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 2/3 | [1] | |
| Company |
Scripps Research Institute
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| Structure |
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Download2D MOL |
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Legumain (LGMN) | Target Info | Modulator | [2] |
| KEGG Pathway | Lysosome | |||
| Antigen processing and presentation | ||||
| Reactome | Trafficking and processing of endosomal TLR | |||
| Vitamin D (calciferol) metabolism | ||||
| MHC class II antigen presentation | ||||
| WikiPathways | Metabolism of steroid hormones and vitamin D | |||
| MHC class II antigen presentation | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT01442636) Drug Eluting Stents In The Critically Ischemic Lower Leg 2. U.S. National Institutes of Health. | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2380). | |||
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