Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0PU9C
|
|||
| Former ID |
DNCL001983
|
|||
| Drug Name |
TTP-448
|
|||
| Indication | Alzheimer disease [ICD-11: 8A20; ICD-10: G30, G30.9; ICD-9: 331] | Phase 2 | [1] | |
| Company |
TransTech Pharma
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Advanced glycosylation end product receptor (AGER) | Target Info | Modulator | [2] |
| Pathway Interaction Database | amb2 Integrin signaling | |||
| Reactome | RIP-mediated NFkB activation via ZBP1 | |||
| DEx/H-box helicases activate type I IFN and inflammatory cytokines production | ||||
| TAK1 activates NFkB by phosphorylation and activation of IKKs complex | ||||
| Advanced glycosylation endproduct receptor signaling | ||||
| TRAF6 mediated NF-kB activation | ||||
| WikiPathways | NRF2 pathway | |||
| Nuclear Receptors Meta-Pathway | ||||
| Cytosolic sensors of pathogen-associated DNA | ||||
| TAK1 activates NFkB by phosphorylation and activation of IKKs complex | ||||
| AGE/RAGE pathway | ||||
| RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways | ||||
| Advanced glycosylation endproduct receptor signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Biopharmaceutical Research Companies are Developing Nearly 100 Medicines for Alzheimer's Disease and Other Dementias. Pharmaceutical Research and Manufacturers of America report. 2012. | |||
| REF 2 | Receptor for advanced glycation endproduct modulators: a new therapeutic target in Alzheimer's disease. Expert Opin Investig Drugs. 2015 Mar;24(3):393-9. | |||
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