Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0PT0U
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| Drug Name |
PMID25666693-Compound-112
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| Drug Type |
Small molecular drug
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| Indication | Cancer related pain [ICD-11: MG30; ICD-10: R52.1, R52.2] | Patented | [1] | |
| Inflammatory pain [ICD-11: MG30.42; ICD-10: R52, G89] | Patented | [1] | ||
| Neuropathic pain [ICD-11: 8E43.0] | Patented | [1] | ||
| Osteoarthritis pain [ICD-11: MG30.31] | Patented | [1] | ||
| Company |
Shionogi & Co., Ltd. KUROSE, Noriyuki
|
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| Structure |
 |
Download2D MOL |
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| Formula |
C21H21ClF3N3O3
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| Canonical SMILES |
C1CN(CC=C1C2=C(C=C(C=N2)CC(CO)O)Cl)C(=O)NC3=CC=C(C=C3)C(F)(F)F
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| InChI |
1S/C21H21ClF3N3O3/c22-18-10-13(9-17(30)12-29)11-26-19(18)14-5-7-28(8-6-14)20(31)27-16-3-1-15(2-4-16)21(23,24)25/h1-5,10-11,17,29-30H,6-9,12H2,(H,27,31)
|
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| InChIKey |
DMTZGKUBPJHALY-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Transient receptor potential cation channel V1 (TRPV1) | Target Info | Antagonist | [1] |
| Target's Patent Info | Transient receptor potential cation channel V1 (TRPV1) | Target's Patent Info | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Inflammatory mediator regulation of TRP channels | ||||
| NetPath Pathway | IL2 Signaling Pathway | |||
| Pathway Interaction Database | Trk receptor signaling mediated by the MAPK pathway | |||
| Trk receptor signaling mediated by PI3K and PLC-gamma | ||||
| Reactome | TRP channels | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014).Expert Opin Ther Pat. 2015 Mar;25(3):291-318. | |||
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