Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0PO0B
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| Former ID |
DIB015679
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| Drug Name |
Cilobradine
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| Synonyms |
Cilobradine; UNII-5O1LL04GJ3; 5O1LL04GJ3; 147541-45-5; Cilobradine [INN]; DK-AH269; SCHEMBL628133; GTPL2355; CHEMBL1436376; ZINC13829377; NCGC00165786-01
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| Drug Type |
Small molecular drug
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| Indication | Cardiac arrhythmias [ICD-11: BC9Z; ICD-9: 427] | Phase 1 | [1], [2] | |
| Company |
Boehringer Ingelheim Corp
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| Structure |
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Download2D MOL |
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| Formula |
C28H38N2O5
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| Canonical SMILES |
COC1=C(C=C(C=C1)CCN2CCCC(C2)CN3CCC4=CC(=C(C=C4CC3=O)OC)OC)OC
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| InChI |
1S/C28H38N2O5/c1-32-24-8-7-20(14-25(24)33-2)9-12-29-11-5-6-21(18-29)19-30-13-10-22-15-26(34-3)27(35-4)16-23(22)17-28(30)31/h7-8,14-16,21H,5-6,9-13,17-19H2,1-4H3/t21-/m0/s1
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| InChIKey |
OBUFMJDDZTXJPY-NRFANRHFSA-N
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| CAS Number |
CAS 147541-45-5
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Hyperpolarization cyclic nucleotide-gated channel (HCN) | Target Info | Modulator | [2], [3], [4] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2355). | |||
| REF 2 | Use-dependent blockade of cardiac pacemaker current (If) by cilobradine and zatebradine. Eur J Pharmacol. 2003 Oct 8;478(2-3):161-71. | |||
| REF 3 | Presynaptic nitric oxide/cGMP facilitates glutamate release via hyperpolarization-activated cyclic nucleotide-gated channels in the hippocampus. Eur J Neurosci. 2011 May;33(9):1611-21. | |||
| REF 4 | Population Pharmacokinetic Data Analysis of Cilobradine, an I f Channel Blocker. Pharm Res.2008 Feb;25(2):359-68. | |||
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