Drug Information
Drug General Information | Top | |||
---|---|---|---|---|
Drug ID |
D0P8AX
|
|||
Drug Name |
1,2-diamino cyclopentane-based derivative 23
|
|||
Synonyms |
PMID26593218-Compound-45
Click to Show/Hide
|
|||
Drug Type |
Small molecular drug
|
|||
Company |
TAKEDA CAMBRIDGE LIMITED TAKEDA PHARMACEUTICAL COMPANY LIMITED
|
|||
Structure |
Download2D MOL |
|||
Formula |
C21H19FN6OS
|
|||
Canonical SMILES |
C1CC(C(C1)NC(=O)C2=CC=CC=C2N3N=CC=N3)NC4=NC5=C(S4)C=CC(=C5)F
|
|||
InChI |
1S/C21H19FN6OS/c22-13-8-9-19-17(12-13)27-21(30-19)26-16-6-3-5-15(16)25-20(29)14-4-1-2-7-18(14)28-23-10-11-24-28/h1-2,4,7-12,15-16H,3,5-6H2,(H,25,29)(H,26,27)/t15-,16-/m0/s1
|
|||
InChIKey |
QOKFERXTHYZAHW-HOTGVXAUSA-N
|
|||
PubChem Compound ID |
Target and Pathway | Top | |||
---|---|---|---|---|
Target(s) | Orexin receptor type 1 (HCRTR1) | Target Info | Antagonist | [1] |
Orexin receptor type 2 (HCRTR2) | Target Info | Antagonist | [1] | |
Target's Patent Info | Orexin receptor type 1 (HCRTR1) | Target's Patent Info | [1] | |
Orexin receptor type 2 (HCRTR2) | Target's Patent Info | [1] | ||
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Reactome | G alpha (q) signalling events | |||
WikiPathways | GPCRs, Class A Rhodopsin-like | |||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
---|---|---|---|---|
REF 1 | Substituted cyclopentanes, tetrahydrofurans and pyrrolidines as orexin-1-receptor antagonists for treatment of various CNS disorders (WO2015/055994; WO2015/124932; WO2015/124934).Expert Opin Ther Pat. 2016;26(3):409-15. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.