Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0P7AS
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| Former ID |
DNC009671
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| Drug Name |
5-Fluoro-6-ethyluridine-5'-O-monophosphate
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| Synonyms |
uridine derivative, 43; CHEMBL473587; SCHEMBL3219344; BDBM27946; {[(2R,3S,4R,5R)-5-(6-ethyl-5-fluoro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C11H16FN2O9P
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| Canonical SMILES |
CCC1=C(C(=O)NC(=O)N1C2C(C(C(O2)COP(=O)(O)O)O)O)F
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| InChI |
1S/C11H16FN2O9P/c1-2-4-6(12)9(17)13-11(18)14(4)10-8(16)7(15)5(23-10)3-22-24(19,20)21/h5,7-8,10,15-16H,2-3H2,1H3,(H,13,17,18)(H2,19,20,21)/t5-,7-,8-,10-/m1/s1
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| InChIKey |
JBBLQWFDKGRNST-VPCXQMTMSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Orotidine 5'-monophosphate decarboxylase (UMPS) | Target Info | Inhibitor | [1] |
| BioCyc | Superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis | |||
| Superpathway of pyrimidine ribonucleotides de novo biosynthesis | ||||
| UMP biosynthesis | ||||
| KEGG Pathway | Pyrimidine metabolism | |||
| Drug metabolism - other enzymes | ||||
| Metabolic pathways | ||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| Reactome | Pyrimidine biosynthesis | |||
| WikiPathways | Metabolism of nucleotides | |||
| Fluoropyrimidine Activity | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents. J Med Chem. 2009 Mar 26;52(6):1648-58. | |||
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