Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0P6GT
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| Former ID |
DNCL003403
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| Drug Name |
Cipro Inhale
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| Synonyms |
Ciloxan; 86393-32-0; Ciprofloxacin hydrochloride monohydrate; Ciprofloxacin hydrochloride hydrate; Ceprimax; Oftacilox; Proquin XR; Floxacipron; Siprogut; Roflazin; Proxacin; Cipropol; Ciprofur; Belmacina; Supraflox; Sophixin; Plenolyt; Phaproxin; Globuce; Felixene; Disfabac; Cunesin; Citeral; Ophaflox; Novoquin; Novidat; Microgan; Loxacid; Keefloxin; Cipronex; Ciflosin; Suiflox; Renator; Quinoflox; Megaflox; Inkamil; Ciproktan; Ciprocinal; Flunas; Piprol; Sepcen; Quipro; Ofitin; Ciflan; Catex; Strox; Lypro; Cilox; Cipad; Cenin; Nixin; Flociprin; Bay
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| Drug Type |
Small molecular drug
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| Indication | Lung infection [ICD-11: CA4Z; ICD-9: 162] | Phase 3 | [1] | |
| Company |
Bayer HealthCare Pharmaceuticals
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| Structure |
 |
Download2D MOL |
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| Formula |
C17H21ClFN3O4
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| Canonical SMILES |
C1CC1N2C=C(C(=O)C3=CC(=C(C=C32)N4CCNCC4)F)C(=O)O.O.Cl
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| InChI |
1S/C17H18FN3O3.ClH.H2O/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24;;/h7-10,19H,1-6H2,(H,23,24);1H;1H2
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| InChIKey |
ARPUHYJMCVWYCZ-UHFFFAOYSA-N
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| CAS Number |
CAS 86393-32-0
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| PubChem Compound ID | ||||
| PubChem Substance ID |
854234, 7849275, 8188389, 12012611, 14780446, 43120033, 50065329, 50125725, 57314943, 80847453, 81043820, 85174197, 92722913, 93305520, 99319459, 104327163, 115354412, 118836555, 125358728, 126603656, 126617874, 126653698, 126663877, 131328379, 131549783, 134338664, 135019641, 143449628, 143837408, 162251668, 163370746, 164788124, 165235301, 175267218, 175611737, 196107810, 223683480, 226414707, 249857489, 252427178
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| ChEBI ID |
CHEBI:59936
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides caccae
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides caccae was decreased by Ciprofloxacin hydrochloride monohydrate (adjusted p-values: 6.13E-06). | |||
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Studied Microbe: Bacteroides fragilis enterotoxigenic
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides fragilis enterotoxigenic was decreased by Ciprofloxacin hydrochloride monohydrate (adjusted p-values: 3.99E-03). | |||
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Studied Microbe: Bacteroides fragilis nontoxigenic
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides fragilis nontoxigenic was decreased by Ciprofloxacin hydrochloride monohydrate (adjusted p-values: 5.86E-06). | |||
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Studied Microbe: Bacteroides ovatus
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides ovatus was decreased by Ciprofloxacin hydrochloride monohydrate (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Bacteroides thetaiotaomicron
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides thetaiotaomicron was decreased by Ciprofloxacin hydrochloride monohydrate (adjusted p-values: 1.01E-05). | |||
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Studied Microbe: Bacteroides uniformis
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides uniformis was decreased by Ciprofloxacin hydrochloride monohydrate (adjusted p-values: 4.53E-05). | |||
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Studied Microbe: Bacteroides vulgatus
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides vulgatus was decreased by Ciprofloxacin hydrochloride monohydrate (adjusted p-values: 5.28E-04). | |||
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Studied Microbe: Bacteroides xylanisolvens
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bacteroides xylanisolvens was decreased by Ciprofloxacin hydrochloride monohydrate (adjusted p-values: 6.65E-07). | |||
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Studied Microbe: Odoribacter splanchnicus
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Odoribacter splanchnicus was decreased by Ciprofloxacin hydrochloride monohydrate (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Parabacteroides distasonis
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Parabacteroides distasonis was decreased by Ciprofloxacin hydrochloride monohydrate (adjusted p-values: 5.51E-07). | |||
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Studied Microbe: Parabacteroides merdae
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Parabacteroides merdae was decreased by Ciprofloxacin hydrochloride monohydrate (adjusted p-values: 4.93E-07). | |||
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Studied Microbe: Prevotella copri
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Prevotella copri was decreased by Ciprofloxacin hydrochloride monohydrate (adjusted p-values: 6.01E-03). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
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Studied Microbe: Bifidobacterium adolescentis
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bifidobacterium adolescentis was decreased by Ciprofloxacin hydrochloride monohydrate (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Bifidobacterium longum
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Bifidobacterium longum was decreased by Ciprofloxacin hydrochloride monohydrate (adjusted p-values: 5.04E-06). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Coriobacteriales | ||||
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Studied Microbe: Collinsella aerofaciens
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Collinsella aerofaciens was decreased by Ciprofloxacin hydrochloride monohydrate (adjusted p-values: 2.73E-07). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eggerthellales | ||||
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Studied Microbe: Eggerthella lenta
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eggerthella lenta was decreased by Ciprofloxacin hydrochloride monohydrate (adjusted p-values: 5.69E-06). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Enterobacterales | ||||
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Studied Microbe: Escherichia coli ED1a
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Escherichia coli ED1a was decreased by Ciprofloxacin hydrochloride monohydrate (adjusted p-values: 5.16E-06). | |||
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Studied Microbe: Escherichia coli IAI1
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Escherichia coli IAI1 was decreased by Ciprofloxacin hydrochloride monohydrate (adjusted p-values: 5.51E-07). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Erysipelotrichales | ||||
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Studied Microbe: Erysipelatoclostridium ramosum
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Erysipelatoclostridium ramosum was decreased by Ciprofloxacin hydrochloride monohydrate (adjusted p-values: 2.42E-05). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Blautia obeum
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Blautia obeum was decreased by Ciprofloxacin hydrochloride monohydrate (adjusted p-values: 4.35E-06). | |||
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Studied Microbe: Clostridioides difficile
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Clostridioides difficile was decreased by Ciprofloxacin hydrochloride monohydrate (adjusted p-values: 1.78E-05). | |||
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Studied Microbe: Clostridium perfringens
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Clostridium perfringens was decreased by Ciprofloxacin hydrochloride monohydrate (adjusted p-values: 5.51E-07). | |||
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Studied Microbe: Coprococcus comes
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Coprococcus comes was decreased by Ciprofloxacin hydrochloride monohydrate (adjusted p-values: 2.04E-05). | |||
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Studied Microbe: Dorea formicigenerans
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Dorea formicigenerans was decreased by Ciprofloxacin hydrochloride monohydrate (adjusted p-values: 2.31E-05). | |||
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Studied Microbe: Enterocloster bolteae
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Enterocloster bolteae was decreased by Ciprofloxacin hydrochloride monohydrate (adjusted p-values: 1.54E-05). | |||
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Studied Microbe: Eubacterium eligens
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eubacterium eligens was decreased by Ciprofloxacin hydrochloride monohydrate (adjusted p-values: 1.53E-05). | |||
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Studied Microbe: Eubacterium rectale
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Eubacterium rectale was decreased by Ciprofloxacin hydrochloride monohydrate (adjusted p-values: 8.98E-04). | |||
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Studied Microbe: Lacrimispora saccharolytica
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Lacrimispora saccharolytica was decreased by Ciprofloxacin hydrochloride monohydrate (adjusted p-values: 3.04E-04). | |||
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Studied Microbe: Roseburia hominis
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Roseburia hominis was decreased by Ciprofloxacin hydrochloride monohydrate (adjusted p-values: 2.79E-03). | |||
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Studied Microbe: Roseburia intestinalis
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Roseburia intestinalis was decreased by Ciprofloxacin hydrochloride monohydrate (adjusted p-values: 4.16E-04). | |||
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Studied Microbe: Ruminococcus bromii
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus bromii was decreased by Ciprofloxacin hydrochloride monohydrate (adjusted p-values: 2.84E-04). | |||
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Studied Microbe: Ruminococcus gnavus
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus gnavus was decreased by Ciprofloxacin hydrochloride monohydrate (adjusted p-values: 3.15E-04). | |||
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Studied Microbe: Ruminococcus torques
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus torques was decreased by Ciprofloxacin hydrochloride monohydrate (adjusted p-values: 5.04E-06). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Lactobacillales | ||||
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Studied Microbe: Lactobacillus paracasei
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Lactobacillus paracasei was decreased by Ciprofloxacin hydrochloride monohydrate (adjusted p-values: 5.04E-06). | |||
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Studied Microbe: Streptococcus parasanguinis
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Streptococcus parasanguinis was decreased by Ciprofloxacin hydrochloride monohydrate (adjusted p-values: 5.51E-07). | |||
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Studied Microbe: Streptococcus salivarius
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Streptococcus salivarius was decreased by Ciprofloxacin hydrochloride monohydrate (adjusted p-values: 5.69E-07). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Veillonellales | ||||
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Studied Microbe: Veillonella parvula
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Veillonella parvula was decreased by Ciprofloxacin hydrochloride monohydrate (adjusted p-values: 5.04E-06). | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022002) | |||
| REF 2 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
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