Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0P5NW
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| Former ID |
DIB001617
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| Drug Name |
SB-236049
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| Synonyms |
SB-236080; SB-238569; Tricyclic broad-spectrum metallo-beta-lactamase inhibitors, SmithKline Beecham
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| Drug Type |
Small molecular drug
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| Indication | Bacterial infection [ICD-11: 1A00-1C4Z; ICD-10: A00-B99] | Terminated | [1] | |
| Company |
SmithKline Beecham Pharmaceuticals
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| Structure |
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Download2D MOL |
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| Formula |
C14H9NO6
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| Canonical SMILES |
CC1=CC2=C(C=N1)C(=O)C3=C(O2)C=C(C(=C3C(=O)O)O)O
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| InChI |
1S/C14H9NO6/c1-5-2-8-6(4-15-5)12(17)10-9(21-8)3-7(16)13(18)11(10)14(19)20/h2-4,16,18H,1H3,(H,19,20)
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| InChIKey |
JQSDDXAUCUZICT-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:68708
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Staphylococcus Beta-lactamase (Stap-coc blaZ) | Target Info | Inhibitor | [1] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Identification of a series of tricyclic natural products as potent broad-spectrum inhibitors of metallo-beta-lactamases. Antimicrob Agents Chemother. 2002 Jun;46(6):1880-6. | |||
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