Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0P3EG
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| Drug Name |
1,3,4-oxadiazole derivative 2
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| Synonyms |
PMID30107136-Compound-Example38
Click to Show/Hide
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| Drug Type |
Small molecule immunotherapy
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| Indication | Hepatitis [ICD-11: DB97.Z] | Patented | [1] | |
| Human immunodeficiency virus infection [ICD-11: 1C62; ICD-9: 42] | Patented | [1] | ||
| Infectious disease [ICD-11: 1A00-CA43.1; ICD-10: A00-B99; ICD-9: 001-139] | Patented | [1] | ||
| Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Patented | [1] | ||
| Company |
AURIGENE DISCOVERY TECHNOLOGIES LIMITED
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| Structure |
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Download2D MOL |
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| Formula |
C22H25N5O5S
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| Canonical SMILES |
COC1=CC=CC=C1C2=NN=C(O2)C(CCC(=O)NCC3=CN=CC=C3)NS(=O)(=O)C4CC4
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| InChI |
1S/C22H25N5O5S/c1-31-19-7-3-2-6-17(19)21-25-26-22(32-21)18(27-33(29,30)16-8-9-16)10-11-20(28)24-14-15-5-4-12-23-13-15/h2-7,12-13,16,18,27H,8-11,14H2,1H3,(H,24,28)/t18-/m0/s1
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| InChIKey |
JHNLLRMWPHPFLP-SFHVURJKSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Programmed cell death protein 1 (PD-1) | Target Info | Inhibitor | [1] |
| Target's Patent Info | Programmed cell death protein 1 (PD-1) | Target's Patent Info | [1] | |
| KEGG Pathway | Cell adhesion molecules (CAMs) | |||
| T cell receptor signaling pathway | ||||
| Reactome | PD-1 signaling | |||
| WikiPathways | T-Cell Receptor and Co-stimulatory Signaling | |||
| Costimulation by the CD28 family | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. | |||
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