Drug Information
Drug General Information | Top | |||
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Drug ID |
D0P0XX
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Drug Name |
Avermectins
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Indication | Pest attack [ICD-11: N.A.] | Investigative | [1] |
Interaction between the Drug and Microbe | Top | |||
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The Abundace of Studied Microbe(s) Regulated by Drug | ||||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
Studied Microbe: Bifidobacterium longum
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Bifidobacterium longum was decreased by Avermectin B1a (adjusted p-values: 9.13E-03). | |||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
Studied Microbe: Blautia obeum
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Blautia obeum was decreased by Avermectin B1a (adjusted p-values: 6.35E-04). | |||
Studied Microbe: Clostridioides difficile
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Clostridioides difficile was decreased by Avermectin B1a (adjusted p-values: 9.80E-03). | |||
Studied Microbe: Clostridium perfringens
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Clostridium perfringens was decreased by Avermectin B1a (adjusted p-values: 4.69E-04). | |||
Studied Microbe: Coprococcus comes
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Coprococcus comes was decreased by Avermectin B1a (adjusted p-values: 6.35E-03). | |||
Studied Microbe: Eubacterium eligens
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Eubacterium eligens was decreased by Avermectin B1a (adjusted p-values: 1.20E-03). | |||
Studied Microbe: Eubacterium rectale
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Eubacterium rectale was decreased by Avermectin B1a (adjusted p-values: 5.69E-04). | |||
Studied Microbe: Roseburia intestinalis
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Roseburia intestinalis was decreased by Avermectin B1a (adjusted p-values: 3.64E-04). | |||
Studied Microbe: Ruminococcus torques
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Ruminococcus torques was decreased by Avermectin B1a (adjusted p-values: 1.01E-05). | |||
The Order in the Taxonomic Hierarchy of the following Microbe(s): Lactobacillales | ||||
Studied Microbe: Lactobacillus paracasei
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Lactobacillus paracasei was decreased by Avermectin B1a (adjusted p-values: 1.23E-03). | |||
Studied Microbe: Streptococcus salivarius
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[2] | |||
Hierarchy | ||||
Abundance Change | Decrease | |||
Experiment Method | High-throughput screening | |||
Description | The abundance of Streptococcus salivarius was decreased by Avermectin B1a (adjusted p-values: 7.77E-03). |
Drug Resistance Mutation (DRM) | Top | |||
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DRM | DRM Info |
References | Top | |||
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REF 1 | The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954. | |||
REF 2 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. |
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