Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0P0VD
|
|||
| Former ID |
DIB008692
|
|||
| Drug Name |
Co-trimoxazole
|
|||
| Indication | Diarrhea [ICD-11: ME05.1; ICD-9: 787.91] | Approved | [1] | |
| Structure |
 |
Download2D MOL |
||
| Formula |
C24H29N7O6S
|
|||
| Canonical SMILES |
CC1=CC(=NO1)NS(=O)(=O)C2=CC=C(C=C2)N.COC1=CC(=CC(=C1OC)OC)CC2=CN=C(N=C2N)N
|
|||
| InChI |
1S/C14H18N4O3.C10H11N3O3S/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2-6H,11H2,1H3,(H,12,13)
|
|||
| InChIKey |
WZRJTRPJURQBRM-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 8064-90-2
|
|||
| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:3770
|
|||
| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Enterobacterales | ||||
|
Studied Microbe: Enterobacteriaceae
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Urinary tract infection | |||
| Description | The abundance of Enterobacteriaceae was decreased by Combination of trimethoprim and sulfamethoxazole. | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Lactobacillales | ||||
|
Studied Microbe: Enterococcus
Show/Hide Hierarchy
|
[2] | |||
| Hierarchy | ||||
| Abundance Change | No significant change | |||
| Experimental Species | Human | Experimental Sample | Faeces | |
| Disease or Condition | Urinary tract infection | |||
| Description | The abundance of Enterococcus was not significantly changed by Combination of trimethoprim and sulfamethoxazole. | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | Effect of norfloxacin, trimethoprim-sulfamethoxazole and nitrofurantoin on fecal flora of women with recurrent urinary tract infections. J Chemother. 1997 Jun;9(3):203-7. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.