Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0OT5L
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| Former ID |
DNC010062
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| Drug Name |
7-propoxy-2H-chromen-2-one
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| Synonyms |
7-Propoxy-chromen-2-one; 7-propoxy-2H-chromen-2-one; 6093-73-8; 7-PROPOXYCOUMARIN; 2H-1-Benzopyran-2-one, 7-propoxy-; CHEMBL568516; 7-Propoxy-2H-1-benzopyran-2-one; AC1LUIIJ; 7-propoxychromen-2-one; CBMicro_001394; SCHEMBL6690398; CTK6E6140; DTXSID90209762; MolPort-000-158-388; ZINC1893420; SMSF0015515; BDBM50303501; STK829267; AKOS001042495; MCULE-7191883680; CB03116; RP26084; KB-46577; CJ-30724; BIM-0001595.P001; DB-072872; FT-0687986
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C12H12O3
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| Canonical SMILES |
CCCOC1=CC2=C(C=C1)C=CC(=O)O2
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| InChI |
1S/C12H12O3/c1-2-7-14-10-5-3-9-4-6-12(13)15-11(9)8-10/h3-6,8H,2,7H2,1H3
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| InChIKey |
FCCCOTWGEKNZMI-UHFFFAOYSA-N
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| CAS Number |
CAS 6093-73-8
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Carbonic anhydrase (CA) | Target Info | Inhibitor | [1] |
| Carbonic anhydrase IX (CA-IX) | Target Info | Inhibitor | [1] | |
| Carbonic anhydrase VI (CA-VI) | Target Info | Inhibitor | [1] | |
| Carbonic anhydrase XII (CA-XII) | Target Info | Inhibitor | [1] | |
| Carbonic anhydrase XIV (CA-XIV) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Nitrogen metabolism | |||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| Pathway Interaction Database | HIF-1-alpha transcription factor network | |||
| Reactome | Reversible hydration of carbon dioxide | |||
| Regulation of gene expression by Hypoxia-inducible Factor | ||||
| WikiPathways | Reversible Hydration of Carbon Dioxide | |||
| miR-targeted genes in muscle cell - TarBase | ||||
| miR-targeted genes in leukocytes - TarBase | ||||
| miR-targeted genes in epithelium - TarBase | ||||
| Vitamin D Receptor Pathway | ||||
| Regulation of Hypoxia-inducible Factor (HIF) by Oxygen | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44. | |||
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