Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0OQ1I
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| Former ID |
DNC002406
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| Drug Name |
Narciclasine
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| Synonyms |
Narciclasine; Lycoricidinol; 29477-83-6; Lycoricidin-A; Narciclasina; NSC 266535; BRN 1087400; NSC266535; Lycorcidinol; Nacriclasine; C14H13NO7; CHEMBL98745; 3,4,4a,5-Tetrahydro-2,3,4,7-tetrahydroxy-(1,3)dioxolo(4,5-j)phenanthridin-6(2H)-one; CHEBI:70169; (2s,3r,4s,4ar)-2,3,4,7-tetrahydroxy-3,4,4a,5-tetrahydro[1,3]dioxolo[4,5-j]phenanthridin-6(2h)-one; (2S,3R,4S,4aR)-2,3,4,7-Tetrahydroxy-3,4,4a,5-tetrahydro-2H-[1,3]dioxolo[4,5-j]phenanthridin-6-one
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| Drug Type |
Small molecular drug
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| Indication | Melanoma [ICD-11: 2C30; ICD-9: 172] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C14H13NO7
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| Canonical SMILES |
C1OC2=C(O1)C(=C3C(=C2)C4=CC(C(C(C4NC3=O)O)O)O)O
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| InChI |
1S/C14H13NO7/c16-6-1-5-4-2-7-13(22-3-21-7)11(18)8(4)14(20)15-9(5)12(19)10(6)17/h1-2,6,9-10,12,16-19H,3H2,(H,15,20)/t6-,9+,10+,12-/m0/s1
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| InChIKey |
LZAZURSABQIKGB-AEKGRLRDSA-N
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| CAS Number |
CAS 29477-83-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
10726, 140223, 600087, 8137270, 8195160, 11406539, 14874084, 43128548, 49963864, 57318683, 80614407, 103067658, 103080295, 103314540, 104135154, 104352786, 117592956, 117638838, 135030024, 137241583, 142846844, 160709382, 162248761, 162831698, 163621022, 163686352, 177748925, 179316330, 184529897, 184812183, 188919983, 226925934, 241049925, 241376600, 248974839, 252157479, 252419324, 252480106
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| ChEBI ID |
CHEBI:70169
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Elongation factor 1A (EF1A) | Target Info | Inhibitor | [1] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Targeting of eEF1A with Amaryllidaceae isocarbostyrils as a strategy to combat melanomas. FASEB J. 2010 Nov;24(11):4575-84. | |||
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