Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0OK1S
|
|||
| Drug Name |
PMID30107136-Compound-Example2
|
|||
| Drug Type |
Small molecule immunotherapy
|
|||
| Indication | Hepatitis [ICD-11: DB97.Z] | Patented | [1] | |
| Human immunodeficiency virus infection [ICD-11: 1C62; ICD-9: 42] | Patented | [1] | ||
| Infectious disease [ICD-11: 1A00-CA43.1; ICD-10: A00-B99; ICD-9: 001-139] | Patented | [1] | ||
| Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Patented | [1] | ||
| Company |
BRISTOL-MYERS SQUIBB COMPANY
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C27H28BrNO3
|
|||
| Canonical SMILES |
CC1=C(C=CC=C1C2=CC=CC=C2)COC3=C(C=C(C=C3)CN4CCCCC4C(=O)O)Br
|
|||
| InChI |
1S/C27H28BrNO3/c1-19-22(10-7-11-23(19)21-8-3-2-4-9-21)18-32-26-14-13-20(16-24(26)28)17-29-15-6-5-12-25(29)27(30)31/h2-4,7-11,13-14,16,25H,5-6,12,15,17-18H2,1H3,(H,30,31)
|
|||
| InChIKey |
QRXBPPWUGITQLE-UHFFFAOYSA-N
|
|||
| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Programmed cell death 1 ligand 1 (PD-L1) | Target Info | Inhibitor | [1] |
| Target's Patent Info | Programmed cell death 1 ligand 1 (PD-L1) | Target's Patent Info | [1] | |
| KEGG Pathway | Cell adhesion molecules (CAMs) | |||
| Reactome | PD-1 signaling | |||
| WikiPathways | Costimulation by the CD28 family | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.