Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0OJ4L
|
|||
| Former ID |
DAP000878
|
|||
| Drug Name |
Hydroxychloroquine
|
|||
| Synonyms |
Hidroxicloroquina; Hidroxicloroquina [INN-Spanish]; Hydroxychlorochin; Gen-Hydroxychloroquine 200mg Tablets; HCQ; Hydroxychloroguine; Hydroxychloroquine (INN);Hydroxychloroquine [INN:BAN]; Hydroxychloroquine Sulfate (1:1) Salt; Hydroxychloroquinum; Hydroxychloroquinum [INN-Latin]; Idrossiclorochina; Idrossiclorochina [DCIT]; Oxichlorochinum; Oxichloroquine; Oxychlorochin; Oxychloroquine; Plaquenil (TN); Polirreumin; Polirreumin (TN); Quensyl; WIN 1258
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Malaria [ICD-11: 1F40-1F45; ICD-10: B50-B64, B54] | Approved | [1], [2] | |
| Therapeutic Class |
Antimalarials
|
|||
| Company |
Concordia Pharmaceuticals Inc
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C18H26ClN3O
|
|||
| Canonical SMILES |
CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO
|
|||
| InChI |
1S/C18H26ClN3O/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21)
|
|||
| InChIKey |
XXSMGPRMXLTPCZ-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 118-42-3
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID |
9255, 597669, 3140459, 5137975, 7979547, 8150104, 8152307, 10505161, 11336117, 11361356, 11462328, 11484852, 11489054, 14777730, 29215442, 29222777, 46508459, 47662363, 47885484, 48416094, 49967663, 57321921, 75004190, 85286187, 96024743, 99302030, 103566848, 104304133, 118262645, 124573764, 126687853, 129756062, 134338155, 134973873, 135702786, 136890426, 137083308, 143201344, 143401603, 160964848, 162180925, 163835395, 163836798, 165716210, 172829147, 174006176, 175607648, 177748295, 178103773, 179039315
|
|||
| ChEBI ID |
CHEBI:5801
|
|||
| ADReCS Drug ID | BADD_D01103 ; BADD_D01104 | |||
| SuperDrug ATC ID |
P01BA02
|
|||
| SuperDrug CAS ID |
cas=000118423
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Toll-like receptor 7 (TLR7) | Target Info | Antagonist | [3] |
| KEGG Pathway | Toll-like receptor signaling pathway | |||
| Measles | ||||
| Influenza A | ||||
| NetPath Pathway | TCR Signaling Pathway | |||
| Panther Pathway | Toll receptor signaling pathway | |||
| Reactome | Trafficking and processing of endosomal TLR | |||
| TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling | ||||
| TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation | ||||
| MyD88 dependent cascade initiated on endosome | ||||
| WikiPathways | Toll-like receptor signaling pathway | |||
| Toll-Like Receptors Cascades | ||||
| MyD88 dependent cascade initiated on endosome | ||||
| Trafficking and processing of endosomal TLR | ||||
| Regulation of toll-like receptor signaling pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7198). | |||
| REF 2 | Emerging drugs for rheumatoid arthritis. Expert Opin Emerg Drugs. 2008 Mar;13(1):175-96. | |||
| REF 3 | TLR7/9 antagonists as therapeutics for immune-mediated inflammatory disorders. Inflamm Allergy Drug Targets. 2007 Dec;6(4):223-35. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.