Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0OB7J
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| Former ID |
DIB001077
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| Drug Name |
NPC-15669
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| Synonyms |
Npc-15669; Npc 15669; UNII-K6JBN2T3Z4; K6JBN2T3Z4; N-(9H-(2,7-Dimethylfluoren-9-ylmethoxy)carbonyl)leucine; N-(((2,7-Dimethyl-9H-fluoren-9-yl)methoxy)carbonyl)-L-leucine; L-Leucine, N-(((2,7-dimethyl-9H-fluoren-9-yl)methoxy)carbonyl)-; AC1L3OOH; 132684-62-9; CHEMBL42385; SCHEMBL8066678; LS-187592; LS-186942; (2S)-2-[(2,7-dimethyl-9H-fluoren-9-yl)methoxycarbonylamino]-4-methylpentanoic acid
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| Drug Type |
Small molecular drug
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| Indication | Inflammation [ICD-11: 1A00-CA43.1] | Discontinued in Phase 1 | [1] | |
| Company |
Scios Inc
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| Structure |
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Download2D MOL |
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| Formula |
C23H27NO4
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| Canonical SMILES |
CC1=CC2=C(C=C1)C3=C(C2COC(=O)NC(CC(C)C)C(=O)O)C=C(C=C3)C
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| InChI |
1S/C23H27NO4/c1-13(2)9-21(22(25)26)24-23(27)28-12-20-18-10-14(3)5-7-16(18)17-8-6-15(4)11-19(17)20/h5-8,10-11,13,20-21H,9,12H2,1-4H3,(H,24,27)(H,25,26)/t21-/m0/s1
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| InChIKey |
SEHPSBSPFWAVPK-NRFANRHFSA-N
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| CAS Number |
CAS 132684-62-9
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Polymorphonuclear neutrophil adhesion (PMNA) | Target Info | Modulator | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001544) | |||
| REF 2 | NPC 15669-modulated human polymorphonuclear neutrophil functional responsiveness: effects on receptor-coupled signal transduction. Br J Pharmacol. 1995 Apr;114(8):1694-702. | |||
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