Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0O9YG
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| Former ID |
DNC000494
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| Drug Name |
Cycloguanil
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| Synonyms |
Cycloguanil; Cycloguanyl; Cycloguanilum; 516-21-2; Chlorcycloguanil; Chlorguanide triazine; UNII-26RM326WVN; BN2410; WR 5473; BN-24-10; CHEMBL747; BRN 0229760; 1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine; 26RM326WVN; QMNFFXRFOJIOKZ-UHFFFAOYSA-N; 1-(p-Chlorophenyl)-4,6-diamino-2,2-dimethyl-1,2-dihydro-s-triazine; 1-(4-chlorophenyl)-6,6-dimethyl-1,3,5-triazine-2,4-diamine; 1-p-Chlorophenyl-1,2-dihydro-2,2-dimethyl-4,6-diamino-s-triazine
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| Drug Type |
Small molecular drug
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| Indication | Malaria [ICD-11: 1F40-1F45; ICD-10: B50-B64, B54] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C11H14ClN5
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| Canonical SMILES |
CC1(N=C(N=C(N1C2=CC=C(C=C2)Cl)N)N)C
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| InChI |
1S/C11H14ClN5/c1-11(2)16-9(13)15-10(14)17(11)8-5-3-7(12)4-6-8/h3-6H,1-2H3,(H4,13,14,15,16)
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| InChIKey |
QMNFFXRFOJIOKZ-UHFFFAOYSA-N
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| CAS Number |
CAS 516-21-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
602626, 6430954, 6440410, 8156438, 11382587, 14823479, 29227667, 46518846, 48415827, 50056269, 50241440, 57325397, 99206041, 99206044, 103200191, 104319417, 106184278, 126408547, 129044396, 131337632, 134339905, 134976109, 136903271, 136903274, 137006527, 137174062, 140329280, 170494913, 179148262, 198941333, 198991512, 223519007, 224828293, 226507347, 249865570, 250134729
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| ChEBI ID |
CHEBI:135029
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Polypeptide deformylase (PDF) | Target Info | Inhibitor | [1] |
| Pathwhiz Pathway | Folate Metabolism | |||
| Pterine Biosynthesis | ||||
| Reactome | E2F mediated regulation of DNA replication | |||
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | ||||
| Metabolism of folate and pterines | ||||
| G1/S-Specific Transcription | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Opportunities and challenges in antiparasitic drug discovery. Nat Rev Drug Discov. 2005 Sep;4(9):727-40. | |||
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