Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0O8AY
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| Former ID |
DIB016338
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| Drug Name |
Combined PR1/WT1 vaccine
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| Synonyms |
Combined PR1/WT1 vaccine (leukemia); Combined PR1/WT1 vaccine (leukemia), NIH; Proteinase 1/Wilms tumor 1 vaccine (leukemia), NIH
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| Drug Type |
Vaccine
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| Indication | Myeloid leukaemia [ICD-11: 2B33.1; ICD-9: 208.9] | Phase 2 | [1] | |
| Company |
National Institutes of Health
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Leukocyte proteinase-3 (PRTN3) | Target Info | . | [2] |
| Wilms tumor protein (WT1) | Target Info | . | [2] | |
| KEGG Pathway | Transcriptional misregulation in cancer | |||
| NetPath Pathway | FSH Signaling Pathway | |||
| IL5 Signaling Pathway | ||||
| Pathway Interaction Database | C-MYB transcription factor network | |||
| p73 transcription factor network | ||||
| Regulation of Telomerase | ||||
| Reactome | Common Pathway of Fibrin Clot Formation | |||
| WikiPathways | Primary Focal Segmental Glomerulosclerosis FSGS | |||
| Integrated Pancreatic Cancer Pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Review of the Results of WT1 Peptide Vaccination Strategies for Myelodysplastic Syndromes and Acute Myeloid Leukemia from Nine Different Studies. Front Immunol. 2015 Feb 4;6:36. | |||
| REF 2 | Leukemia-associated antigen-specific T-cell responses following combined PR1 and WT1 peptide vaccination in patients with myeloid malignancies. Blood. 2008 Jan 1;111(1):236-42. | |||
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