Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0O7WT
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| Former ID |
DNC010206
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| Drug Name |
9-[2-(1-Phosphonobutan-2-yloxy)ethyl]hypoxanthine
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C11H17N4O5P
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| Canonical SMILES |
CCC(CP(=O)(O)O)OCCN1C=NC2=C1N=CNC2=O
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| InChI |
1S/C11H17N4O5P/c1-2-8(5-21(17,18)19)20-4-3-15-7-14-9-10(15)12-6-13-11(9)16/h6-8H,2-5H2,1H3,(H,12,13,16)(H2,17,18,19)
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| InChIKey |
WLWRLYCRISPQDH-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Plasmodium Hypoxanthine-guanine phosphoribosyltransferase (Malaria LACZ) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Purine metabolism | |||
| Drug metabolism - other enzymes | ||||
| Metabolic pathways | ||||
| Pathwhiz Pathway | Purine Metabolism | |||
| Reactome | Purine salvage | |||
| WikiPathways | Nucleotide Metabolism | |||
| Mesodermal Commitment Pathway | ||||
| Endoderm Differentiation | ||||
| Metabolism of nucleotides | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum h... Bioorg Med Chem. 2009 Sep 1;17(17):6218-32. | |||
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