Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0O3QW
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| Former ID |
DIB002575
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| Drug Name |
Trodusquemine
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| Synonyms |
Produlestan; Trodulamine; Aminosterol 1436; MSI-1436; Aminosterols (obesity, type 2 diabetes), Genaera
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| Drug Type |
Small molecular drug
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| Indication | Breast cancer [ICD-11: 2C60-2C65] | Phase 1 | [1] | |
| Obesity [ICD-11: 5B81; ICD-10: E66; ICD-9: 278] | Phase 1 | [2] | ||
| Company |
Genaera
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| Structure |
 |
Download2D MOL |
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| Formula |
C37H72N4O5S
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| Canonical SMILES |
CC(C)C(CCC(C)C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)NCCCNCCCCNCCCN)C)O)C)OS(=O)(=O)O
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| InChI |
1S/C37H72N4O5S/c1-26(2)34(46-47(43,44)45)13-10-27(3)30-11-12-31-35-32(15-17-37(30,31)5)36(4)16-14-29(24-28(36)25-33(35)42)41-23-9-22-40-20-7-6-19-39-21-8-18-38/h26-35,39-42H,6-25,38H2,1-5H3,(H,43,44,45)/t27-,28-,29+,30-,31+,32+,33-,34-,35+,36+,37-/m1/s1
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| InChIKey |
WUJVPODXELZABP-FWJXURDUSA-N
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| CAS Number |
CAS 186139-09-3
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Protein-tyrosine phosphatase 1B (PTP1B) | Target Info | Inhibitor | [3] |
| KEGG Pathway | Adherens junction | |||
| Insulin signaling pathway | ||||
| NetPath Pathway | FSH Signaling Pathway | |||
| Panther Pathway | Cadherin signaling pathway | |||
| Pathway Interaction Database | Insulin Pathway | |||
| Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) | ||||
| Signaling events mediated by PTP1B | ||||
| Calcineurin-regulated NFAT-dependent transcription in lymphocytes | ||||
| Signaling events mediated by TCPTP | ||||
| IGF1 pathway | ||||
| EGF receptor (ErbB1) signaling pathway | ||||
| Posttranslational regulation of adherens junction stability and dissassembly | ||||
| PDGFR-beta signaling pathway | ||||
| N-cadherin signaling events | ||||
| Reactome | Integrin alphaIIb beta3 signaling | |||
| Regulation of IFNG signaling | ||||
| Regulation of IFNA signaling | ||||
| Growth hormone receptor signaling | ||||
| WikiPathways | Insulin Signaling | |||
| Growth hormone receptor signaling | ||||
| Leptin signaling pathway | ||||
| Interferon gamma signaling | ||||
| Interferon alpha/beta signaling | ||||
| Integrin alphaIIb beta3 signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 2 | ClinicalTrials.gov (NCT00806338) An Ascending Multi-Dose, Tolerance and Pharmacokinetic Study in Obese or Overweight Type 2 Diabetic Volunteers. U.S. National Institutes of Health. | |||
| REF 3 | Inhibition of PTP1B by trodusquemine (MSI-1436) causes fat-specific weight loss in diet-induced obese mice. Obesity (Silver Spring). 2010 Aug;18(8):1516-23. | |||
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