Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0O3NG
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| Former ID |
DNC000564
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| Drug Name |
Dimaprit
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| Synonyms |
Dimaprit; 65119-89-3; UNII-ZZQ699148P; BRN 2350552; CHEMBL12344; 3-(dimethylamino)propyl imidothiocarbamate; 3-(dimethylamino)propyl carbamimidothioate; CARBAMIMIDOTHIOIC ACID, 3-(DIMETHYLAMINO)PROPYL ESTER; CHEBI:81389; ZZQ699148P; Pseudourea, 2-(3-(dimethylamino)propyl)-2-thio-; [3-(carbamimidoylsulfanyl)propyl]dimethylamine; Carbamimidothioicacid, 3-(dimethylamino)propyl ester; C6H15N3S; AE-641/25069014; Tocris-0506; AC1Q1UAQ; Prestwick0_000983; Prestwick3_000983; Prestwick2_000983; Prestwick1_000983; AC1L1F4E; BSPBio_001045
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C6H15N3S
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| Canonical SMILES |
CN(C)CCCSC(=N)N
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| InChI |
1S/C6H15N3S/c1-9(2)4-3-5-10-6(7)8/h3-5H2,1-2H3,(H3,7,8)
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| InChIKey |
OLHQOJYVQUNWPL-UHFFFAOYSA-N
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| CAS Number |
CAS 65119-89-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
5021259, 7979095, 8151956, 11112685, 11113535, 11467011, 11468131, 11486682, 15265190, 16961065, 26751746, 29222222, 47365385, 47662484, 47959949, 48334687, 49699373, 49846697, 49900669, 50901984, 56314095, 57309579, 57321594, 85209056, 85788602, 91567534, 95509074, 96024151, 103124474, 103173420, 104302459, 117373937, 124882517, 124882518, 128825496, 132562708, 134339961, 135008316, 135650186, 137041679, 143456392, 162221383, 162890531, 179236213, 198949187, 221672748, 223446363, 226710935
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| ChEBI ID |
CHEBI:81389
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histamine H2 receptor (H2R) | Target Info | Agonist | [2] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Gastric acid secretion | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Histamine H2 receptor mediated signaling pathway | ||||
| Pathwhiz Pathway | Intracellular Signalling Through Histamine H2 Receptor and Histamine | |||
| Gastric Acid Production | ||||
| Reactome | Histamine receptors | |||
| G alpha (s) signalling events | ||||
| WikiPathways | Monoamine GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| Secretion of Hydrochloric Acid in Parietal Cells | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1248). | |||
| REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
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