Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0NY6U
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| Former ID |
DIB019388
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| Drug Name |
PMID24673130C26
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| Synonyms |
GTPL8134; BDBM50011536
Click to Show/Hide
|
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C13H9FN4
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| Canonical SMILES |
C1=CC(=CC(=C1)F)C2=NC3=C(C=C2)N=CN=C3N
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| InChI |
1S/C13H9FN4/c14-9-3-1-2-8(6-9)10-4-5-11-12(18-10)13(15)17-7-16-11/h1-7H,(H2,15,16,17)
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| InChIKey |
TWTLUQDFSDYZKO-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | MEK kinase kinase 4 (MAP4K4) | Target Info | Inhibitor | [1] |
| NetPath Pathway | FSH Signaling Pathway | |||
| TCR Signaling Pathway | ||||
| Panther Pathway | Apoptosis signaling pathway | |||
| Pathway Interaction Database | EPHB forward signaling | |||
| TNF receptor signaling pathway | ||||
| Ceramide signaling pathway | ||||
| Direct p53 effectors | ||||
| Reactome | Oxidative Stress Induced Senescence | |||
| WikiPathways | Insulin Signaling | |||
| MAPK Signaling Pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Discovery of selective 4-Amino-pyridopyrimidine inhibitors of MAP4K4 using fragment-based lead identification and optimization. J Med Chem. 2014 Apr 24;57(8):3484-93. | |||
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