Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0NY2E
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| Drug Name |
E-64D
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| Synonyms |
E64D; E64d; Aloxistatin; Aloxistatin [INN]; Aloxistatina; Aloxistatina [Spanish]; Aloxistatine; Aloxistatine [French]; Aloxistatinum; Aloxistatinum [Latin]; BRN 5354546; C17H30N2O5; CCRIS 1934; CHEMBL63440; E 64c ethyl ester; E 64d; EP 453; EST; EST (pharmaceutical); L5W337AOUR; Loxistatin; MLS000028372; NSC 694281; SMR000058552; UNII-L5W337AOUR
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| Drug Type |
Small molecular drug
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| Indication | Middle East Respiratory Syndrome (MERS) [ICD-11: 1D64] | Preclinical | [1], [2] | |
| Severe acute respiratory syndrome (SARS) [ICD-11: 1D65] | Preclinical | [1], [2] | ||
| Therapeutic Class |
Antiviral Agents
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| Structure |
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Download2D MOL |
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| Formula |
C17H30N2O5
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| Canonical SMILES |
CCOC(=O)C1C(O1)C(=O)NC(CC(C)C)C(=O)NCCC(C)C
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| InChI |
1S/C17H30N2O5/c1-6-23-17(22)14-13(24-14)16(21)19-12(9-11(4)5)15(20)18-8-7-10(2)3/h10-14H,6-9H2,1-5H3,(H,18,20)(H,19,21)/t12-,13-,14-/m0/s1
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| InChIKey |
SRVFFFJZQVENJC-IHRRRGAJSA-N
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| CAS Number |
CAS 88321-09-9
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:101381
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | HUMAN cathepsin L (CTSL) | Target Info | Blocker | [1], [2] |
| References | Top | |||
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| REF 1 | Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47. | |||
| REF 2 | The Cysteine Protease Inhibitor, E64d, Reduces Brain Amyloid- and Improves Memory Deficits in Alzheimer's Disease Animal Models by Inhibiting Cathepsin B, but Not BACE1, -Secretase Activity. J Alzheimers Dis. 2011;26(2):387-408. | |||
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