Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0NU1W
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| Former ID |
DNC005190
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| Drug Name |
3,6,8-Tribromo-dibenzo[1,4]dioxin-1-ol
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| Synonyms |
Spongiadioxin C; CHEMBL185753; 3,6,8-Tribromo-dibenzo[1,4]dioxin-1-ol; 3,6,8-tribromooxanthren-1-ol; dibenzo[b,e][1,4]dioxin-1-ol, 3,6,8-tribromo-; 3,6,8-tribromodibenzo[b,e][1,4]dioxin-1-ol; AC1LCT04; BDBM50150791; 3,6,8-tribromodibenzo-p-dioxin-1-ol; 460092-06-2
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C12H5Br3O3
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| Canonical SMILES |
C1=C(C=C2C(=C1O)OC3=C(O2)C(=CC(=C3)Br)Br)Br
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| InChI |
1S/C12H5Br3O3/c13-5-1-7(15)11-9(3-5)18-12-8(16)2-6(14)4-10(12)17-11/h1-4,16H
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| InChIKey |
XZPITRJUKODSMI-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Arachidonate 15-lipoxygenase (15-LOX) | Target Info | Inhibitor | [1] |
| BioCyc | Resolvin D biosynthesis | |||
| Lipoxin biosynthesis | ||||
| KEGG Pathway | Arachidonic acid metabolism | |||
| Linoleic acid metabolism | ||||
| Metabolic pathways | ||||
| Serotonergic synapse | ||||
| NetPath Pathway | IL4 Signaling Pathway | |||
| Panther Pathway | Inflammation mediated by chemokine and cytokine signaling pathway | |||
| Pathwhiz Pathway | Arachidonic Acid Metabolism | |||
| Pathway Interaction Database | IL4-mediated signaling events | |||
| WikiPathways | Arachidonic acid metabolism | |||
| Eicosanoid Synthesis | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase. J Med Chem. 2004 Jul 29;47(16):4060-5. | |||
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