Drug Information
Drug General Information | Top | |||
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Drug ID |
D0NT1S
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Former ID |
DNCL002584
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Drug Name |
CB-10-01
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Drug Type |
Vaccine
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Indication | Melanoma [ICD-11: 2C30; ICD-9: 172] | Phase 2 | [1] | |
Company |
Cosmo Pharmaceuticals
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Target and Pathway | Top | |||
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Target(s) | Telomerase reverse transcriptase (TERT) | Target Info | . | [2] |
NetPath Pathway | IL2 Signaling Pathway | |||
Pathway Interaction Database | Validated targets of C-MYC transcriptional activation | |||
Regulation of Telomerase | ||||
IL2 signaling events mediated by PI3K | ||||
Regulation of nuclear beta catenin signaling and target gene transcription | ||||
HIF-1-alpha transcription factor network | ||||
Reactome | Formation of the beta-catenin:TCF transactivating complex |
References | Top | |||
---|---|---|---|---|
REF 1 | ClinicalTrials.gov (NCT00925314) A Study of Transgenic Lymphocyte Immunization (TLI) Against Telomerase in Subjects With Stage III Melanoma. U.S. National Institutes of Health. | |||
REF 2 | Telomerase immunity from bench to bedside: round one. J Transl Med. 2007 Feb 26;5:12. |
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