Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0NL2L
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| Former ID |
DNC009725
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| Drug Name |
3-[7'-(Methoxy)-napht-2'-yl]-quinuclidine-2-ene
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| Synonyms |
CHEMBL478981; SCHEMBL2422138; KZWBNNXTWZPPPP-UHFFFAOYSA-N; BDBM50270302; 3-[7''-(Methoxy)-napht-2''-yl]-quinuclidine-2-ene; 3-(6-methoxy-2-naphthyl)-1-azabicyclo[2.2.2]oct-2-ene
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C18H19NO
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| Canonical SMILES |
COC1=CC2=C(C=C1)C=C(C=C2)C3=CN4CCC3CC4
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| InChI |
1S/C18H19NO/c1-20-17-5-4-14-10-16(3-2-15(14)11-17)18-12-19-8-6-13(18)7-9-19/h2-5,10-13H,6-9H2,1H3
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| InChIKey |
KZWBNNXTWZPPPP-UHFFFAOYSA-N
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| CAS Number |
CAS 894079-46-0
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Squalene synthetase (FDFT1) | Target Info | Inhibitor | [1] |
| BioCyc | Cholesterol biosynthesis II (via 24,25-dihydrolanosterol) | |||
| Cholesterol biosynthesis III (via desmosterol) | ||||
| Cholesterol biosynthesis I | ||||
| Superpathway of cholesterol biosynthesis | ||||
| Epoxysqualene biosynthesis | ||||
| KEGG Pathway | Steroid biosynthesis | |||
| Metabolic pathways | ||||
| Biosynthesis of antibiotics | ||||
| Panther Pathway | Cholesterol biosynthesis | |||
| Pathwhiz Pathway | Steroid Biosynthesis | |||
| Reactome | Cholesterol biosynthesis | |||
| PPARA activates gene expression | ||||
| Activation of gene expression by SREBF (SREBP) | ||||
| WikiPathways | Statin Pathway | |||
| Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) | ||||
| Activation of Gene Expression by SREBP (SREBF) | ||||
| SREBP signalling | ||||
| Cholesterol Biosynthesis | ||||
| Cholesterol biosynthesis | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Quinuclidine derivatives as potential antiparasitics. Antimicrob Agents Chemother. 2007 Nov;51(11):4049-61. | |||
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