Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0NJ4G
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| Former ID |
DNC007192
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| Drug Name |
5,7-dichloro-1H-indole-2,3-dione
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| Synonyms |
5,7-Dichloroisatin; 6374-92-1; 5,7-Dichloroindoline-2,3-dione; 5,7-Dichloro-1H-indole-2,3-dione; 1H-Indole-2,3-dione, 5,7-dichloro-; NSC26045; 5,7-dichloro-2,3-dihydro-1H-indole-2,3-dione; MLS002639083; AYGGQJHJRFZDFH-UHFFFAOYSA-N; 5,7-dichloro-1H-benzo[d]azolidine-2,3-dione; 5,7-dichlor-1h-indol-2,3-dion; EINECS 228-928-3; Indole-2,3-dione, 5,7-dichloro-; Isatin,7-dichloro-; PubChem22561; AC1Q3MQY; Isatin, 5,7-dichloro-; ACMC-1B7TC; NCIMech_000038; Isatin-based compound, 53; Cambridge id 5228213; AC1Q3I9X; CBDivE_012174
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C8H3Cl2NO2
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| Canonical SMILES |
C1=C(C=C(C2=C1C(=O)C(=O)N2)Cl)Cl
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| InChI |
1S/C8H3Cl2NO2/c9-3-1-4-6(5(10)2-3)11-8(13)7(4)12/h1-2H,(H,11,12,13)
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| InChIKey |
AYGGQJHJRFZDFH-UHFFFAOYSA-N
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| CAS Number |
CAS 6374-92-1
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Liver carboxylesterase (CES1) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Drug metabolism - other enzymes | |||
| Metabolic pathways | ||||
| Pathway Interaction Database | E2F transcription factor network | |||
| WikiPathways | NRF2 pathway | |||
| Nuclear Receptors Meta-Pathway | ||||
| Heroin metabolism | ||||
| Irinotecan Pathway | ||||
| Fluoropyrimidine Activity | ||||
| Phase I biotransformations, non P450 | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. J Med Chem. 2007 Apr 19;50(8):1876-85. | |||
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