Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0NF6F
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| Former ID |
DNC001465
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| Drug Name |
Trichostatin A
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| Synonyms |
trichostatin A; 58880-19-6; Trichostatin A (TSA); TSA; Trichostatin; Tricostatin A; UNII-3X2S926L3Z; CHEBI:46024; (2E,4E,6R)-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide; GNF-PF-1011; RTKIYFITIVXBLE-QEQCGCAPSA-N; 3X2S926L3Z; 7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide; 2,4-Heptadienamide, 7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-; 7-[4-(DIMETHYLAMINO)PHENYL]-N-HYDROXY-4,6-DIMETHYL-7-OXO-2,4-HEPTADIENAMIDE
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C17H22N2O3
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| Canonical SMILES |
CC(C=C(C)C=CC(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C
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| InChI |
1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1
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| InChIKey |
RTKIYFITIVXBLE-QEQCGCAPSA-N
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| CAS Number |
CAS 58880-19-6
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| PubChem Compound ID | ||||
| PubChem Substance ID |
639194, 830546, 841099, 7890895, 10299571, 12013760, 14709930, 14710659, 14800564, 16291220, 17425541, 17435668, 24844209, 24900542, 26697088, 26755794, 26755795, 36887655, 46371223, 46391613, 46506659, 48409855, 49975235, 50111294, 53790917, 56310830, 56310866, 56310944, 56311019, 56311051, 56311436, 56311486, 56311582, 56311740, 56311744, 56311808, 56312025, 56312066, 56312070, 56312071, 56312281, 56312376, 56312416, 56312510, 56312643, 56312984, 56312986, 56313049, 56313053, 56313217
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| ChEBI ID |
CHEBI:46024
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histone deacetylase (HDAC) | Target Info | Inhibitor | [2], [3], [4] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7005). | |||
| REF 2 | Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene transcription in Schistosoma mansoni. Mol Biochem Parasitol. 2009 Nov;168(1):7-15. | |||
| REF 3 | Histone deacetylase inhibitors in cancer therapy: latest developments, trends and medicinal chemistry perspective. Anticancer Agents Med Chem. 2007 Sep;7(5):576-92. | |||
| REF 4 | Two histone deacetylase inhibitors, trichostatin A and sodium butyrate, suppress differentiation into osteoclasts but not into macrophages. Blood. 2003 May 1;101(9):3451-9. | |||
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