Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0N8BA
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| Drug Name |
Bicyclic pyrimidine derivative 2
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| Synonyms |
PMID27718763-Compound-4
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| Drug Type |
Small molecular drug
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| Company |
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
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| Structure |
 |
Download2D MOL |
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| Formula |
C22H20F4N4O3
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| Canonical SMILES |
CC1(CN2C(=CC(=NC2=O)OCC3=CC(=C(C=C3)OC4=CN=CC(=C4)C(F)(F)F)F)N1C)C
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| InChI |
1S/C22H20F4N4O3/c1-21(2)12-30-19(29(21)3)8-18(28-20(30)31)32-11-13-4-5-17(16(23)6-13)33-15-7-14(9-27-10-15)22(24,25)26/h4-10H,11-12H2,1-3H3
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| InChIKey |
PPKNPJKYLRQSCE-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Platelet-activating factor acetylhydrolase (PLA2G7) | Target Info | Inhibitor | [1] |
| Target's Patent Info | Platelet-activating factor acetylhydrolase (PLA2G7) | Target's Patent Info | [1] | |
| KEGG Pathway | Ether lipid metabolism | |||
| Metabolic pathways | ||||
| Biosynthesis of antibiotics | ||||
| Pathway Interaction Database | Lissencephaly gene (LIS1) in neuronal migration and development | |||
| WikiPathways | IL1 and megakaryotyces in obesity | |||
| Synthesis, Secretion, and Deacylation of Ghrelin | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Inhibitors of phospholipase A2 and their therapeutic potential: an update on patents (2012-2016).Expert Opin Ther Pat. 2017 Feb;27(2):217-225. | |||
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