Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0N7WW
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| Former ID |
DNCL001716
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| Drug Name |
RVX-208
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| Drug Type |
Small molecular drug
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| Indication | Alzheimer disease [ICD-11: 8A20; ICD-10: G30, G30.9] | Phase 1/2 | [1], [2] | |
| Company |
Resverlogix
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| Structure |
 |
Download2D MOL
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| Canonical SMILES |
CC1=CC(=CC(=C1OCCO)C)C2=NC(=O)C3=C(N2)C=C(C=C3OC)OC
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| PubChem Compound ID | ||||
| PubChem Substance ID |
50126585, 135305721, 141708486, 163409471, 163643112, 163821164, 163847684, 164041687, 165248799, 165248805, 171061159, 172093762, 172096849, 172096851, 174496643, 178103613, 180675855, 185996728, 189053150, 198972554, 208013481, 208013599, 210275516, 210281164, 223254663, 223617444, 224195824, 226511513, 242059987, 244837717, 250182634, 250214367, 252043688, 252126596, 252160855, 252316669, 252442904, 252450338, 252559941
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Bromodomain-containing protein 4 (BRD4) | Target Info | Modulator | [3], [4] |
| WikiPathways | Chemical Compounds to monitor Proteins | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7034). | |||
| REF 2 | ClinicalTrials.gov (NCT00768274) Safety, Pharmacokinetic Study of RVX000222 in Healthy Subjects and Subjects With Low HDL Cholesterol. U.S. National Institutes of Health. | |||
| REF 3 | Targeting bromodomains: epigenetic readers of lysine acetylation.Nat Rev Drug Discov.2014 May;13(5):337-56. | |||
| REF 4 | RVX-208, an inducer of ApoA-I in humans, is a BET bromodomain antagonist.PLoS One.2013 Dec 31;8(12):e83190. | |||
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