Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0N5YD
|
|||
| Former ID |
DNCL003041
|
|||
| Drug Name |
Nepicastat oral
|
|||
| Synonyms |
SYN117
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Post-traumatic stress disorder [ICD-11: 6B40; ICD-10: F43.1, F62.0; ICD-9: 309.81, 304.2] | Phase 2 | [1], [2] | |
| Company |
Biotie Therapies
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C14H16ClF2N3S
|
|||
| Canonical SMILES |
C1CC2=C(CC1N3C(=CNC3=S)CN)C=C(C=C2F)F.Cl
|
|||
| InChI |
1S/C14H15F2N3S.ClH/c15-9-3-8-4-10(1-2-12(8)13(16)5-9)19-11(6-17)7-18-14(19)20;/h3,5,7,10H,1-2,4,6,17H2,(H,18,20);1H/t10-;/m0./s1
|
|||
| InChIKey |
DIPDUAJWNBEVOY-PPHPATTJSA-N
|
|||
| CAS Number |
CAS 170151-24-3
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Dopamine beta hydroxylase (DBH) | Target Info | Inhibitor | [3] |
| BioCyc | Catecholamine biosynthesis | |||
| KEGG Pathway | Tyrosine metabolism | |||
| Metabolic pathways | ||||
| Panther Pathway | Adrenaline and noradrenaline biosynthesis | |||
| Dopamine receptor mediated signaling pathway | ||||
| Pathwhiz Pathway | Catecholamine Biosynthesis | |||
| Tyrosine Metabolism | ||||
| WikiPathways | Monoamine Transport | |||
| Biogenic Amine Synthesis | ||||
| Metabolism of amino acids and derivatives | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00641511) Pharmacogenetic Clinical Trial of Nepicastat for Post Traumatic Stress Disorder (PTSD). U.S. National Institutes of Health. | |||
| REF 2 | ClinicalTrials.gov (NCT01704196) A Multi-Center Trial of Nepicastat for Cocaine Dependence. U.S. National Institutes of Health. | |||
| REF 3 | Catecholamine modulatory effects of nepicastat (RS-25560-197), a novel, potent and selective inhibitor of dopamine-beta-hydroxylase. Br J Pharmacol. 1997 Aug;121(8):1803-9. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.