Drug Information
Drug General Information | Top | |||
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Drug ID |
D0N5VK
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Drug Name |
TSR-042
|
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Drug Type |
Monoclonal antibody
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Indication | Advanced malignancy [ICD-11: 2A00-2F9Z] | Phase 1 | [1] | |
Metastatic cancer [ICD-11: 2D50-2E2Z; ICD-10: C76-C80] | Phase 1 | [2] | ||
Solid tumour/cancer [ICD-11: 2A00-2F9Z] | Phase 1 | [1] | ||
Company |
TESARO Waltham, MA
|
Target and Pathway | Top | |||
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Target(s) | Programmed cell death protein 1 (PD-1) | Target Info | . | [1] |
KEGG Pathway | Cell adhesion molecules (CAMs) | |||
T cell receptor signaling pathway | ||||
Reactome | PD-1 signaling | |||
WikiPathways | T-Cell Receptor and Co-stimulatory Signaling | |||
Costimulation by the CD28 family |
References | Top | |||
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REF 1 | Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730. | |||
REF 2 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) |
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