Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0N4PW
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| Former ID |
DIB008148
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| Drug Name |
iOWH032
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| Synonyms |
IOWH-032; CFTR inhibitors (diarrhea), BioFocus
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| Indication | Diarrhea [ICD-11: ME05.1; ICD-9: 787.91] | Phase 2 | [1] | |
| Company |
The Institute for OneWorld Health
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| Structure |
 |
Download2D MOL |
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| Formula |
C22H15Br2N3O4
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| Canonical SMILES |
C1=CC=C(C=C1)OC2=CC=C(C=C2)CNC(=O)C3=NC(=NO3)C4=CC(=C(C(=C4)Br)O)Br
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| InChI |
1S/C22H15Br2N3O4/c23-17-10-14(11-18(24)19(17)28)20-26-22(31-27-20)21(29)25-12-13-6-8-16(9-7-13)30-15-4-2-1-3-5-15/h1-11,28H,12H2,(H,25,29)
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| InChIKey |
DSFNLJXHXBIKDS-UHFFFAOYSA-N
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| CAS Number |
CAS 1191252-49-9
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | cAMP-dependent chloride channel (CFTR) | Target Info | Inhibitor | [2] |
| KEGG Pathway | ABC transporters | |||
| cAMP signaling pathway | ||||
| AMPK signaling pathway | ||||
| Gastric acid secretion | ||||
| Pancreatic secretion | ||||
| Bile secretion | ||||
| Vibrio cholerae infection | ||||
| Reactome | ABC-family proteins mediated transport | |||
| WikiPathways | ABC-family proteins mediated transport | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT02111304) Efficacy of iOWH032 in Dehydrating Cholera. U.S. National Institutes of Health. | |||
| REF 2 | Developing novel antisecretory drugs to treat infectious diarrhea. Future Med Chem. 2011 Aug;3(10):1317-25. | |||
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