Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D0N4IV
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| Former ID |
DIB014240
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| Drug Name |
S-3304
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| Synonyms |
BPHA; BPHA, Shionogi; MMP inhibitors, Shionogi; Matrix metalloproteinase inhibitor, Shionogi
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Phase 1/2 | [1] | |
| Company |
Shionogi & Co Ltd
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| Structure |
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Download2D MOL |
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| Formula |
C24H20N2O4S2
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| Canonical SMILES |
CC1=CC=C(C=C1)C#CC2=CC=C(S2)S(=O)(=O)NC(CC3=CNC4=CC=CC=C43)C(=O)O
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| InChI |
1S/C24H20N2O4S2/c1-16-6-8-17(9-7-16)10-11-19-12-13-23(31-19)32(29,30)26-22(24(27)28)14-18-15-25-21-5-3-2-4-20(18)21/h2-9,12-13,15,22,25-26H,14H2,1H3,(H,27,28)/t22-/m1/s1
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| InChIKey |
YWCLDDLVLSQGSZ-JOCHJYFZSA-N
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| CAS Number |
CAS 203640-27-1
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Matrix metalloproteinase (MMP) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00078390) Study of S-3304 in Patients With Locally Advanced Non-Small Cell Lung Cancer. U.S. National Institutes of Health. | |||
| REF 2 | Safety, tolerability and pharmacokinetics of oral S-3304, a novel matrix metalloproteinase inhibitor, in single and multiple dose escalation studies in healthy volunteers. Int J Clin Pharmacol Ther. 2005 Jun;43(6):282-93. | |||
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