Drug Information
Drug General Information | Top | |||
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Drug ID |
D0N3XP
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Former ID |
DIB019890
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Drug Name |
G749
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Synonyms |
G-749
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL
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Formula |
C25H25BrN6O2
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Canonical SMILES |
CN1CCC(CC1)NC2=NC3=C(C(=O)NC=C3Br)C(=N2)NC4=CC=C(C=C4)OC5=CC=CC=C5
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InChI |
1S/C25H25BrN6O2/c1-32-13-11-17(12-14-32)29-25-30-22-20(26)15-27-24(33)21(22)23(31-25)28-16-7-9-19(10-8-16)34-18-5-3-2-4-6-18/h2-10,15,17H,11-14H2,1H3,(H,27,33)(H2,28,29,30,31)
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InChIKey |
SXWMIXPJPNCXQQ-UHFFFAOYSA-N
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CAS Number |
CAS 1457983-28-6
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Fms-like tyrosine kinase 3 (FLT-3) | Target Info | Inhibitor | [1] |
Tyrosine-protein kinase Mer (MERTK) | Target Info | Inhibitor | [1] | |
KEGG Pathway | Cytokine-cytokine receptor interaction | |||
Hematopoietic cell lineage | ||||
Pathways in cancer | ||||
Transcriptional misregulation in cancer | ||||
Acute myeloid leukemia | ||||
Central carbon metabolism in cancer | ||||
NetPath Pathway | TSH Signaling Pathway | |||
Reactome | Cell surface interactions at the vascular wall | |||
WikiPathways | Cell surface interactions at the vascular wall |
References | Top | |||
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REF 1 | G-749, a novel FLT3 kinase inhibitor, can overcome drug resistance for the treatment of acute myeloid leukemia. Blood. 2014 Apr 3;123(14):2209-19. |
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